Bumetanide

Drug #108

Bumetanide is a loop diuretic and a sulfonamide derivative. Bumetanide is used as an antihypertensive agent. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. It increases the urination and decrease the amount of water retained in the body.Bumetanide is administered orally, intramuscularly or intravenously. Bumetanide is a sulfonamide-type loop diuretic used in the management of edema associated with congestive heart failure, cirrhosis, and renal disease such as nephrotic syndrome.

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Primary Characteristics

It is of Synthetic origin and belongs to Sulfamoylbenzoic acid.

It belongs to Na-K-Cl triple cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Loop pharmacological group.

Molecular Weight: 364.4 · pK_a: 0.3, 4, 10 · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Bumetanide.

Pharmacokinetics

Absorption: Bumetanide has an oral bioavailability is 80.5% (±15.5%).

Distribution: Bumetanide has a volume of distribution is 9.5 -35 litre. plasma protein binding is 95%.

Elimination: plasma half-life is 1.0-1.5 hr, renal excretion is 80%.

Indications

Bumetanide is primarily indicated in conditions like Congestive heart failure, Hypercalcaemia, Hypertension, Nephrotic syndrome, Oedema, Oliguria due to renal failure, Prohylaxis of acid aspiration in obstetric patients, Pulmonary edema.

Contraindications

Bumetanide is contraindicated in conditions like Gout, Renal failure, Anuria, Hepatic coma, Severe elecrolyte imbalance.

Dosage

Bumetanide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.75 mg	0.75 mg	Every 24h	PO,Slow IV	Every 2-3 Hours in a Day
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown8 interactions

3 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Bumetanide in overdosage may give rise to further complications which include Encephalopathy , Ototoxicity .

Bumetanide produces potentially life-threatening effects which include Hypersensitivity reactions, Electrolyte and volume depletion, Electrolyte disturbances, Volume disturbances. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Bumetanide are Cardiovascular shock, Electrolyte imbalance , Embolism , Volume depletion, Thrombosis.

Bumetanide is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Diaphoresis, Diarrhea, Dizziness, Dry mouth, Ear pain, Erectile dysfunction, Headache, Hypotension , Musculoskeletal discomfort, Nausea, Nipple tenderness, Premature ejaculation, Rashes , Renal failure, Vomiting .

Warnings / Precautions

Bumetanide should be used with caution in patients with medical history, including any allergies (especially drug allergies), liver or kidney diseases, blood disorders or hearing impairments. Dizziness on standing may occur, to avoid dizziness or lightheadedness when rising from a seated or lying position, get up slowly. This medication should be used only when clearly needed during pregnancy or lactation. Caution is advised when this drug is used in the elderly patients.

Available Brands

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Multi-Ingredient Combinations

Tabs

0.5 mg

Storage Conditions

Bumetanide should be stored Tab, Inj.

Drug Classification

1.16.2 — Loop diuretics

Manufacturers

Manufacturers of Bumetanide in Pakistan:

Pacific