Brompheniramine (Maleate)

Drug #105

Brompheniramine (Maleate) is antihistaminic agent. Brompheniramine (Maleate) is probably effective for temporary relief of hay fever (allergic rhinitis affecting the mucous membranes of the eyes and respiratory tract caused by pollen of certain plants) and upper respiratory allergic symptoms, such as itchy, watery eyes, sneezing.

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Primary Characteristics

It is of Synthetic origin and belongs to Propylamine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 435.3 · pK_a: 3.9 · Solubility in Water: 1 in 5 · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Brompheniramine (Maleate).

Molecular structure of Brompheniramine (Maleate)

Pharmacokinetics

Absorption: Brompheniramine (Maleate) has an oral bioavailability is 60% (±10%), pre-systemic (first-pass) metabolism accounts for 35% (±15%).

Distribution: Brompheniramine (Maleate) has a volume of distribution is 2.5-10 l/kg. plasma protein binding is 72%.

Elimination: it is metabolised via Hepatic, plasma half-life is 25 hr, renal excretion is >90%.

Indications

Brompheniramine (Maleate) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Dermatitis, NSAID associated ulceration, Urticaria.

Brompheniramine (Maleate) is also indicated for secondary conditions like Asthma.

Contraindications

Brompheniramine (Maleate) is contraindicated in conditions like Porphyria, General dose.

Dosage

Brompheniramine (Maleate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.114 mg/kg	0.114 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0.175 mg/kg	0.175 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
0.175 mg/kg	0.175 mg/kg	Every 8h	oral

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Brompheniramine (Maleate) in overdosage may give rise to further complications which include Hallucinations , Brain damage or epilepsy , Sleep disturbances , Aggression, Grand-mal seizures .

Brompheniramine (Maleate) produces potentially life-threatening effects which include Agranulocytosis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Brompheniramine (Maleate) are Convulsions , Coma, Hypotension.

Brompheniramine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Dry mouth, Sedation .

Warnings / Precautions

Brompheniramine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously, because irritation or lesion may occur.

Available Brands

None recorded.

Storage Conditions

Brompheniramine (Maleate) should be stored Elixir. Tab, Caps, Inj.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis