Bromocriptine (Mesylate)
Bromocriptine (Mesylate) is the 2-bromo derivative of a-ergocryptine. Bromocriptine an ergotamine (an alkaloid with vasoconstrictor action), is a dopamine agonist and mimics the action of dopamine. The effects of bromocriptine are similar to those fo Levodopa. The drug produces little effects in patients who do not react to Levodopa. But Bromocriptine (Mesylate) is often used with Levodopa in patients responding to drug therapy.
Primary Characteristics
It is of Synthetic origin and belongs to Ergot.
It belongs to D2 agonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.
Molecular Weight: 750.8 · pKa: 4.9 · Solubility in Water: 1 in 1250 · Solubility in Alcohol: 1 in 43 · Non-proprietary name: Bromocriptine (Mesylate).
Pharmacokinetics
Absorption: Bromocriptine (Mesylate) has an oral bioavailability is 35% (±5%), pre-systemic (first-pass) metabolism accounts for 72.5% (±2.5%).
Distribution: Bromocriptine (Mesylate) has a volume of distribution is 1-3.7 l/kg. plasma protein binding is 96%.
Elimination: it is metabolised via Hepatic, plasma half-life is 15 hr, renal excretion is 6%.
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Indications
Bromocriptine (Mesylate) is primarily indicated in conditions like Acromegaly, Anovulatory infertility, Cyclical benign breast disease, Galactorrhoea, Hyperprolactinaemia, Hypogonadism, Infertility, Infertility without hyperprolactinaemia, Parkinsonism, Parkinson's disease, Premenstrual syndrome, Premenstural syndrome, Prolactinoma, Suppression of lactation.
Bromocriptine (Mesylate) is also indicated for secondary conditions like Lactation.
Contraindications
Bromocriptine (Mesylate) is contraindicated in conditions like Hypertension in pregnancy, Toxaemia of pregnancy, Neurological disorders, Breast disease, Hypersensitivity to the drug.
Dosage
Bromocriptine (Mesylate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.875 mg | 1.875 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Bromocriptine (Mesylate) in overdosage may give rise to further complications which include Parkinsonism , Pleural effusion .
The signs and symptoms that are produced after acute overdosage of Bromocriptine (Mesylate) are Vomiting, Drowsiness, Hallucinations , Postural hypotension, Dizziness, Nausea, Sweating .
Bromocriptine (Mesylate) is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Dizziness, Fatigue, Hallucination , Nausea, Postural hypotension, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.9.1 — Drugs used in parkinsonism
- 2.18.6 — Ovulation stimulants