DrugInfoSys

Raloxifene (HCl)

Drug #993

Raloxifene (HCl) is a nonsteroidal antioestrogen with some oestrogenic activity. Raloxifene (HCl) is used in women who are at great risk of post-menopausal osteoporosis. Raloxifene (HCl) is also indicated for prophylaxis and treatment of vertebral fractures in postmenopausal women.

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Primary Characteristics

Raloxifene (HCl) is also known as Raloxifene.

It belongs to Benzothiophene.

It belongs to Oestrogen Agonist pharmacological group on the basis of mechanism of action and also classified in Hormones pharmacological group. It is also classified under Hormones .

Molecular Weight: 510 · Solubility in Water: very slightly · Solubility in Alcohol: null · Non-proprietary name: Raloxifene (HCl).

Molecular structure of Raloxifene (HCl)

Pharmacokinetics

Absorption: Raloxifene (HCl) has an oral bioavailability is 30% (±30%).

Distribution: Raloxifene (HCl) has a volume of distribution is 2348 l/kg. plasma protein binding is >95%.

Elimination: plasma half-life is 27 hr, renal excretion is < 6 %.

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Indications

Raloxifene (HCl) is primarily indicated in conditions like Prevention of osteoporosis, Sedation with amnesia.

Raloxifene (HCl) is also indicated for secondary conditions like Postmenopausal disorders.

Contraindications

Raloxifene (HCl) is contraindicated in conditions like Thrombosis, Vaginal bleeding.

Dosage

Raloxifene (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
60 mg60 mgEvery 24hPO
Paediatric Dosage (20kg)
0 – 0——Not applicable in paeds
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Raloxifene (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Depression, Fever, Flatulence, Gastroenteritis , Hot flushes, Increased intracranial pressure, Insomnia, Migraine , Nausea, Rashes , Vomiting , Weight gain.

Warnings / Precautions

Raloxifene should be used with caution in patients with any allergy (especially drug allergies), blood clots, heart failure, cancer or liver disease. This drug should be stopped at least 3 days before and during long periods of inactivity (e.g.bed rest). Blood clots, though unlikely, are more common when not moving. Avoid long periods of sitting or lying down during travel. This drug should not be used during pregnancy or lactation. This drug should not be used in children.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
60 mg

Multi-Ingredient Combinations

Tabs
60 mg

Storage Conditions

Raloxifene (HCl) should be stored Tab.

Drug Classification

  1. 1.18.4 — Estrogens, their combinations and related preparations
  2. 2.18.14 — Drugs affecting bone metabolism

Manufacturers

Manufacturers of Raloxifene (HCl) in Pakistan:

AmarantCCLHanselLexiconLillyMacterPulseRotexStandpharmTagmaValor