Protirelin
Protirelin is a hypothalamic releasing hormone which stimulates release of thyrotropin from anterior lobe of pituitary.It also has Prolactin releasing activity. Protirelin (Tartrate) is a . Protirelin (Tartrate) is used parentrally in the diagnosis of hypothyroidism.
Primary Characteristics
Protirelin is also known as Protirelin (Tartrate).
It is of Synthetic origin and belongs to Tripeptide.
It is also classified under Diagnostic Aids , Psychotherapeutic Drugs .
Molecular Weight: 362.4 · Solubility in Water: soluble · Solubility in Alcohol: null · Non-proprietary name: Protirelin Tartrate.
Pharmacokinetics
None recorded.
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Indications
Protirelin is primarily indicated in conditions like Assessment of thyroid function, Coma, Diagnostic test for thyroid cancer differentiation, Graves disease, Oliguria due to renal failure, Radiological contrast agent, Unconciousness.
Protirelin is also indicated for secondary conditions like Neurological disorders, Spinal cord trauma, Subarachnoid haemorrhage.
Contraindications
None recorded.
Dosage
Protirelin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 300 mcg | 300 mcg | — | IV | |
| 1.75 mg | 1.75 mg | — | Slow IV | For 10 Days |
| Paediatric Dosage (20kg) | ||||
| 0.02 mg/kg | 0.02 mg/kg | — | Intra Venous | Single Dose |
| Neonatal Dosage (3kg) | ||||
| 0.025 mg/kg | 0.025 mg/kg | — | Intravenous | Single dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Protirelin in overdosage may give rise to further complications which include Convulsions , Bronchospasm .
The signs and symptoms that are produced after acute overdosage of Protirelin are Hypotension, Unconsciousness.
Protirelin is known to cause more or less tolerable side effects which are usually transient. These include Altered pulse rate, BP alteration, Dizziness, Facial flushing, Flushing, Headache, Hot flushes, Micturition, Nausea.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.8 — Thyroid & antithyroid preparations
- 2.24.5 — Psychostimulants, nootropics, and neurotonics
Manufacturers
Manufacturers of Protirelin in Pakistan: