Primary Characteristics
It is of origin and belongs to Phenylcyclohexylamine .
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent pharmacological group. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 329.9 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Pramiverine.
Pharmacokinetics
Distribution: Pramiverine (HCl) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Pramiverine (HCl) is primarily indicated in conditions like Colic, GI motality disorder, Pain, Smooth muscle spasm.
Contraindications
Pramiverine (HCl) is contraindicated in conditions like Glucoma, Urinary retention (adynamic bladder), Prostatic hypertrophy, Mega colon, Intestinal obstruction.
Dosage
Pramiverine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.75 mg | 3.75 mg | — | IM,Slow IV | As Required |
| 2 mg | 2 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
None recorded.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics
Manufacturers
Manufacturers of Pramiverine (HCl) in Pakistan: