DrugInfoSys

Plasma Protein Fraction

Drug #971

Plasma Protein Fraction is a sterile solution of selected proteins derived from the blood plasma of adult human donors. It contains protein, of which about 83-90% is albumin and the remainder is a and ß globulins. Plasma Protein Fraction is used as a substitute for plasma in treating non-hemorrhagic shock and as a source of protien for intravenous nutrition.

← Previous drugNext drug →

Primary Characteristics

It is of Natural origin and belongs to Protein .

It is classified in Blood Product Derivative pharmacological group. It is also classified under Plasma Protein Fractions .

Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Plasma Protein Fraction.

Molecular structure of Plasma Protein Fraction

Pharmacokinetics

Distribution: Plasma Protein Fraction has a volume of distribution is . plasma protein binding is .

Elimination: it is metabolised via , plasma half-life is , renal excretion is .

Advertisement

Indications

Plasma Protein Fraction is primarily indicated in conditions like Hypovolaemia.

Plasma Protein Fraction is also indicated for secondary conditions like Cardiac insufficiency.

Contraindications

Plasma Protein Fraction is contraindicated in conditions like Anaemia, Congestive heart failure, Hypersensitivity to any component of product.

Dosage

Plasma Protein Fraction's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
500 ml500 ml—IV-infAt rate not exceeding 10 ml/min.
Paediatric Dosage (20kg)
25 ml/kg25 ml/kg—IV InfusionInfuse at 10 ml/min.As required
Neonatal Dosage (3kg)
2525—IV InfusionAs required

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Plasma Protein Fraction is known to cause more or less tolerable side effects which are usually transient. These include Back pain, Flushing, Headache, Hypotension , Nausea, Urticaria.

Warnings / Precautions

Rapid infusion of Plasma Protein Fraction (greater than 10mL/minute) has produced hypotension in patients undergoing surgery or in the preoperative or postoperative period. Blood pressure should be monitored during use and infusion slowed or ceased if sudden hypotension occurs. Plasma Protein Fraction does not provide coagulation factors and therefore does not correct coagulation disorders.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inf
50 g/100ml
Inj
50 g/100ml

Storage Conditions

Plasma Protein Fraction should be stored .

Drug Classification

  1. 1.11.1 — Plasma substitutes

Manufacturers

Manufacturers of Plasma Protein Fraction in Pakistan:

NabiqasimPopular Int.