Pefloxacin
Pefloxacin is a fluoroquinolone antibiotic with actions and uses similar to those of ciprofloxacin. Pefloxacin is used to treat a variety of bacterial infections like respiratory tract, ENT, skin, urinary tract infections etc. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Pefloxacin is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.
Primary Characteristics
Pefloxacin is also known as Pefloxacin Mesilate.
It is of Semi Synthetic origin and belongs to Fluoroquinolone.
It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Quinolone pharmacological group.
Molecular Weight: 465.5 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Pefloxacin.
Pharmacokinetics
Distribution: Pefloxacin has a plasma protein binding is 20-30%.
Elimination: it is metabolised via hepatic, plasma half-life is 8 - 13 hr.
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Indications
Pefloxacin is primarily indicated in conditions like Acne, Bacterial infections, Bronchitis, Burns, Conjuctivitis, Cystitis, Dysenteries, Folliculitis, Impetigo, Otitis media, Pneumonia, Prostatitis, Pyelonephritis, Respiratory tract infections, Sedation in intensive care, Sinusitis, Superficial infections, Surgical infections, Tonsillitis, Urethritis.
Contraindications
Pefloxacin is contraindicated in conditions like Hypersensitivity.
Dosage
Pefloxacin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 400 mg | 400 mg | Every 12h | IV Inf | Over 60 min. |
| 400 mg | 400 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Pefloxacin is known to cause more or less tolerable side effects which are usually transient. These include Articular pain, GI upset, Headache, Insomnia, Muscle pain.
Warnings / Precautions
Interference in Pathology
Pefloxacin may interfere in the diagnosis of Thyroid Function Test.
Available Brands
Click on a strength to view available brands.
Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.6.2.2.2 — Quinolones
Manufacturers
Manufacturers of Pefloxacin in Pakistan: