Paroxetine

Drug #956

Paroxetine (HCl) is antidepressant and belongs to selective serotonin reuptake inhibitors (SSRIs). Paroxetine (HCl) is used to treat obsessive-compulsive disorders and panic disorders. Paroxetine (HCl) is a phenylpiperidine derivative that is prepared by chemical synthesis. Paroxetine (HCl) is optically active and the (-) nantiomer is used clinically. Paroxetine (HCl) is not available in any combination preparations. Paroxetine (HCl) is administered orally.

← Previous drug Next drug →

Primary Characteristics

Paroxetine is also known as Paroxetine (HCl), .

It is of Synthetic origin and belongs to Phenyl Piperidine.

It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 365.8 · pK_a: 9.9 · Solubility in Water: 1 in 125 · Solubility in Alcohol: >1 in 5 · Non-proprietary name: Paroxetine (HCl).

Pharmacokinetics

Absorption: Paroxetine has an oral bioavailability is 50% (±50%).

Distribution: Paroxetine has a volume of distribution is 3.1-28 l/kg. plasma protein binding is 95%.

Elimination: it is metabolised via hepatic, plasma half-life is 24hr, renal excretion is 24(19-29)%.

Indications

Paroxetine is primarily indicated in conditions like Acute dystonia, Depression, Depression accompanied by anxiety, Depressive illness and post-traumatic stress disorder, Monotherapy (epilepsy), Obsessive-compulsive disorders, Panic disorders, Post traumatic stress disorder, Social phobia.

Contraindications

Paroxetine is contraindicated in conditions like Epilepsy, Heart failure, Mania, Seizures, Hypersensitivity.

Dosage

Paroxetine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 mg	20 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown22 interactions

5 interactions

Major4 interactions

Moderate4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Paroxetine in overdosage may give rise to further complications which include Convulsions , Myopathy , Mania , Oro-facial dystonia, Impotence , Angioedema , Urticaria , Tremors , Glaucoma , Extrapyramidal symptoms, Galactorrhea.

The signs and symptoms that are produced after acute overdosage of Paroxetine are Somnolence, Coma, Nausea & vomiting, Fever, Dilated pupils, Sweating , Tremor, Irritability, Tachycardia , Dry mouth, BP changes, Involuntary muscle contraction.

Paroxetine is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Anorexia , Anxiety, Blurred vision, Confusion, Constipation , Decrease in libido, Diaphoresis, Diarrhea, Dizziness, Dreams abnormality, Ejaculatory disturbances, Ejaculatory failure, Elevation of liver enzymes, Flatulence, Hallucination , Headache, Hyperreflexia, Hyponatremia, Hypotension , Increased intracranial pressure, Insomnia, Jaundice , Mucous membrane bleeding, Myoclonus, Nausea, Nervousness, Palpitation, Postural hypotension, Rashes , Skin bleeding, SomnolenceX, Suicidal attempts, Sweating , Taste disturbances, Thrombocytopenia, Urinary retensionX, Vasodilation , Vomiting , Weakness, Xerostomia , Yawning.

Warnings / Precautions

Paroxetine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with pre-existing kidney disease, liver disease, seizure disorder, thyroid disease, history of substance abuse or if have any allergy, in patients with a history of mania, to patients receiving oral anticoaagulants, in cardiac patients, in epilepsy, narrow angle glaucoma, patients already receiving neuroleptics, patients treating with drugs that give an increase risk of bleeding and in patients with a known tendency for bleeding or those with predisposing conditions.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

12.5 mg 20 mg 25 mg 37.5 mg 50 mg

Storage Conditions

Paroxetine should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression

Manufacturers

Manufacturers of Paroxetine in Pakistan: