Bezafibrate
Bezafibrate is anti-hyperlipidimic agent. Bezafibrate is used to reduce high blood fats and cholesterol levels.
Primary Characteristics
It is of Synthetic origin and belongs to Priopionic Acid.
It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action.
Molecular Weight: 361.8 · pKa: 3.61 · Solubility in Water: 1 in 62500 · Solubility in Alcohol: > 1 in 1000 · Non-proprietary name: Bezafibrate.
Pharmacokinetics
Absorption: Bezafibrate has an oral bioavailability is 100%.
Distribution: Bezafibrate has a volume of distribution is 17 litre. plasma protein binding is 94-96%.
Elimination: plasma half-life is 0.87-4.82 hr.
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Indications
Bezafibrate is primarily indicated in conditions like Hypercholesterolaemia, Prophylaxis of NSAID-associated gastric or duodenal ulcer.
Contraindications
Bezafibrate is contraindicated in conditions like Renal failure, Liver cirrhosis, Nephrotic syndrome, Hypoalbuminaemia.
Dosage
Bezafibrate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 200 mg | 200 mg | Every 8h | PO | With or after food. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Bezafibrate is known to cause more or less tolerable side effects which are usually transient. These include GI distention, Myositic syndrome , Nausea.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.12.6 — Lipid-regulating drugs /Anti-atheromas
Manufacturers
Manufacturers of Bezafibrate in Pakistan: