Oxaprozin

Drug #946

Oxaprozin is NSAID (non steroidal antinflammatory drug). Oxaprozin is one of the newest of the propionic acid derivative. It relieves pain and reduces inflammation and fever. It has a very long half life and it can be given once a day. Because of this long half life dose adjustment should be made at intervals no shorter than five days to two weeks.

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Primary Characteristics

It belongs to Propionic Acid.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 293.3 · pK_a: 4.3 · Solubility in Water: Insoluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Oxaprozin.

Pharmacokinetics

Distribution: Oxaprozin has a plasma protein binding is > 99 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 40 - 50 hr, renal excretion is 65 %.

Indications

Oxaprozin is primarily indicated in conditions like Osteoarthritis, Rheumatoid arthritis.

Contraindications

Oxaprozin is contraindicated in conditions like Haemorrhage, GI diseases.

Dosage

Oxaprozin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 mg	600 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Oxaprozin in overdosage may give rise to further complications which include Agranulocytosis , Anemia , Pancreatitis , Leucopenia.

Oxaprozin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , BP alteration, CNS depression, Dysuria, Edema, GI hemorrhage, GI ulceration, Increased intracranial pressure, Nausea, Rashes , Rectal bleeding, Serum sickness, Sleep disturbance, StomatitisX, Vomiting , Weight gain, Weight loss.

Warnings / Precautions

Oxaprozin should be used with caution in patients with any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies (especially drug allergies). It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Do not take aspirin without consulting the doctor (check the ingredients of any nonprescription medication because it may contain aspirin). Caution is advised when this drug is used in the elderly. It should be used during pregnancy or lactation only if clearly needed. Use of this drug during the last 6 months of pregnancy is not recommended.

Interference in Pathology

Oxaprozin may interfere in the diagnosis of Abnormal LFTs .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

600 mg

Storage Conditions

Oxaprozin should be stored Tab.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers

Manufacturers of Oxaprozin in Pakistan:

Flow Macter