Olanzapine

Drug #945

Olanzapine is atypical antipsychotic agent similar in chemical structure and in mechanism of action to clozapine. The development of it was based on the atypical profile of clozapine which suggests that the antipsychotic effects are due to clozapine's interaction at a number of different receptors rather than at a single receptor type. Like clozapine, it binds to , dopamine, histamine (H-1), muscarinic, and serotonin type- 2 (5-HTÁ) receptors. It has a reduced incidence of extrapyramidal reactions and appears to have a low potential for drug interactions. Clinically, it may be effective for both negative and positive symptoms of schizophrenia. Final FDA approval was granted October 1, 1996 for the treatment of schizophrenia.

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Primary Characteristics

Olanzapine is also known as Olanzapine Citrate.

It is of Synthetic origin and belongs to Benzodiazepines.

It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 312.4 · Solubility in Water: Insoluble · Solubility in Alcohol: null · Non-proprietary name: Olanzapine.

Pharmacokinetics

Distribution: Olanzapine has a volume of distribution is 1000 litre. plasma protein binding is 93%.

Elimination: it is metabolised via 40% via liver, plasma half-life is 30-38 hr, renal excretion is 57%.

Indications

Olanzapine is primarily indicated in conditions like Moderate to severe mania associated with bipolar disorder, Nausea and vomiting, Psychosis, Schizophrenia.

Olanzapine is also indicated for secondary conditions like Mania.

Contraindications

Olanzapine is contraindicated in conditions like Narrow-angle glaucoma.

Dosage

Olanzapine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.5 mg	7.5 mg	Every 24h	PO	Maximum dose 20 mg.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown5 interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Olanzapine in overdosage may give rise to further complications which include Seizures , Extrapyramidal syndrome.

Olanzapine is known to cause more or less tolerable side effects which are usually transient. These include Constipation , dizziness, Dry mouth, Increased appetite, Orthostatic hypotension, Peripheral edema, SomnolenceX, Weight gain.

Warnings / Precautions

Olanzepine should be used with caution in patients with liver or heart disease, low blood pressure, breast cancer, stroke, diabetes, seizures (any neurological problems), prostate problems, narrow angle glaucoma, intestinal disease or any allergy. Caution is advised to avoid overheating and also excessive body water loss by very strenuous exercise or exposure to extreme heat. Alcohol use may add to the dizziness and drowsiness effect of this drug. It should be used with caution in the elderly. It should be used only when clearly needed during pregnancy.

Interference in Pathology

Olanzapine may interfere in the diagnosis of Fasting blood glucose testing.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

10 mg 5 mg

Caps

12 mg

Tabs

10 mg 5 mg 7.5 mg

Multi-Ingredient Combinations

Caps

6 mg

Storage Conditions

Olanzapine should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders

Manufacturers

Manufacturers of Olanzapine in Pakistan: