Bethanechol (Cl)

Drug #93

Bethanechol is a cholinergic agonist and is mainly muscarinic in action. Chemically, it has the structural features of both methacholine and carbachol. Bethanechol (Cl) is resistant to hydrolysis by cholinesterase. Bethanechol (Cl) is used to stimulate the smooth muscle contraction of the urinary bladder and gastrointestinal tract. Administered orally or subcutaneously.

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Primary Characteristics

It is of Synthetic origin and belongs to Carbamate Ammonium Salt.

It belongs to Cholinergic muscarinic agonist pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.

Molecular Weight: 196.7 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Bethanecol (Cl) · pH: 6 · Isotonic value: 3.05.

Pharmacokinetics

Absorption: Bethanechol (Cl) has an oral bioavailability is 2.5% (±2.5%).

Elimination: plasma half-life is 2 hr.

Indications

Bethanechol (Cl) is primarily indicated in conditions like Adynamic ileus, Gastric atony, Gastric retention, Mega colon, Reflux oesophagitis, Urinary retention.

Bethanechol (Cl) is also indicated for secondary conditions like Urinary retention.

Contraindications

Bethanechol (Cl) is contraindicated in conditions like Asthma, Epilepsy, Hyperthyroidism, Myocardial infarction, Parkinsonism, Bradycardia, Vagotonia, Intestinal obstruction, Hypotension, Pronounced vasomotor instability, Urinary outflow obstruction, Gastric obstruction, Recent intestinal anastomosis.

Dosage

Bethanechol (Cl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.25 mg/kg	0.25 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0.6 mg/kg	0.6 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
0.6 mg/kg	0.6 mg/kg	Every 8h	Oral	-

Drug Interactions

Unknown5 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Bethanechol (Cl) are Severe hypotension.

Bethanechol (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Frequent of micturition, Lower abdominal cramps, Nausea, Vomiting .

Warnings / Precautions

Avoid bethanecol in patients with intestinal or urinary obstruction, asthma or obstructive airway disease, cardiovascular disease including bradycardia or heart block or recent myocardial infraction, in hypotension, epilepsy, parkinsonism, hyperthyroidism, peptic ulcer and during pregnancy.

Available Brands

None recorded.

Storage Conditions

Bethanechol (Cl) should be stored Inj. Tab.

Drug Classification

1.29 — Drugs used in renal, bladder, and prostatic disorders