Betaxolol (HCl)

Drug #92

Betaxolol (HCl) is a cardioselective beta blocker. Betaxolol (HCl) is anti-hypertensive and antianginal agent. It reduces fluid formation in the eye and reduced pressure in the eye produced by glaucoma

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Primary Characteristics

It is of Synthetic origin and belongs to Amino Propanol.

It belongs to Beta-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiglaucoma pharmacological group. It is also classified under Opthalmic Products .

Molecular Weight: 343.9 · pK_a: 9.38 · Solubility in Water: 1 in 3 · Solubility in Alcohol: freely soluble · Non-proprietary name: Betaxolol (HCl).

Pharmacokinetics

Absorption: Betaxolol (HCl) has an oral bioavailability is 84.5% (±4.5%).

Distribution: Betaxolol (HCl) has a volume of distribution is 6.12 ± 0.44 l/kg. plasma protein binding is 50%.

Elimination: plasma half-life is 13-24 hr, renal excretion is major.

Indications

Betaxolol (HCl) is primarily indicated in conditions like Angina pectoris, Glucoma, Hypertension.

Contraindications

Betaxolol (HCl) is contraindicated in conditions like Asthma, Heart failure, Bradycardia, Second or third degree A-V block.

Dosage

Betaxolol (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.375 %	0.375 %	Every 24h	Ophthalmic	drops.
15 mg	15 mg	Every 24h	PO	Gradually Increased
30 mg	30 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

1 interaction

Major5 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Betaxolol (HCl) produces potentially life-threatening effects which include Bronchospasm . Careful monitoring is needed with proper medical management.

Betaxolol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Cold hands and feet, Fatigue, GI upset, Headache, Impotence, Raynaud's phenomenon, Sleep disturbance, Tiredness .

Warnings / Precautions

Betaxolol (beta-blocker) should not be given to patients with bronchospasm, asthma, with history of obstructive airway disease, metabolic acidosis, partial heart block, sinus bradycardia or psoriasis. The dose may need to reduce in patients with renal (kidney) or hepatic (liver) dysfunction. Patients with long term treatment with beta-blockers should have their medication discontinued gradually over a period of 1 to 2 weeks, because it may result in angina, myocardial infraction (MI), ventricular arrhythmia or death. This drug should be used only if clearly needed during pregnancy or lactation.

Available Brands

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Single Ingredient

Eye Drops

0.25 %w/v 0.5 %w/v

Storage Conditions

Betaxolol (HCl) should be stored Eye Drops.

Drug Classification

1.21.4.2 — Beta blockers

Manufacturers

Manufacturers of Betaxolol (HCl) in Pakistan:

Atco Innvotek Novartis