Mecobalamin
Also known as: Methyl cabolamine
Mecobalamin is a vitamin B-12 co-enzyme that occurs in blood and cerebrospinal fluid. Mecobalamin is taken by nerve tissues more actively and extensively than other homologues of vitamin B12. Mecbalamine accerelates the synthesis of nucleic acid in bone marrow as well as promotes the maturation and division of erythroblast and haeme synthesis, resulting in an increase in erythrocyte (RBCs) production.
Primary Characteristics
Mecobalamin is also known as Methyl cabolamine.
It is of Natural origin and belongs to Co-enzyme.
It is classified in Peripheral Neuropathies pharmacological group. It is also classified under Vitamins .
Molecular Weight: 1344.4 · Solubility in Water: 1 in 83 · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Mecobalamin.
Pharmacokinetics
Elimination: it is metabolised via Hepatic, plasma half-life is 12.5 hr, renal excretion is 40-80%. also excreted in bile.
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Indications
Mecobalamin is primarily indicated in conditions like Congenital cobalamine malabsorption, Congenital intrinsic factor deficiency, Homocystenemia, Methylmalonylacidurias, Peripheral neuropathy, Pernicious anaemia, Post gastrectomy vit B-12 deficiency, Transcobalamin II deficiency, Vitamin B12 deficiency.
Contraindications
Mecobalamin is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Mecobalamin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 250 – 1000 mcg | — | — | IM, IV | Alternate days for 1 to 2 weeks followed by 250 mcg weekly. Then for maintenance administer 1000 mcg every 2-3 weeks. |
| 500 mcg | 500 mcg | Every 8h | PO | Treatment depends upon extent of iron deficiency. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mecobalamin produces potentially life-threatening effects which include Cardiac arrhythmia, Aggravation of acidosis. Careful monitoring is needed with proper medical management.
Mecobalamin is known to cause more or less tolerable side effects which are usually transient. These include Allergic hypersensitivity reactions, Anorexia , Diarrhea, Headache, Hot sensation, Nausea, Skin RashX, Sweating , Tachycardia, Vomiting .
Warnings / Precautions
Interference in Pathology
Mecobalamin may interfere in the diagnosis of false + result for intrinsic factor antibody.
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.10.1 — Antianemia drugs
- 2.27 — Vitamins, minerals, tonics, and other susbstances
Manufacturers
Manufacturers of Mecobalamin in Pakistan: