Meclofenamic Acid
Meclofenamic Acid is anthranilic acid derivative similar to mefenamic acid, is an NSAID (non-steroidal anti-inflammatory drug). Meclofenamic Acid is given by mouth in musculoskeletal and joints disorders such as osteoarthritis and rheumatoid arthritis, in mild to moderate pain.The antiinflammatory effects of these drugs may result from the peripheral inhibition of prostaglandin synthesis secondary to inhibition of the enzyme cyclooxygenase. Prostaglandins sensitize pain receptors and their inhibition is thought to be responsible for the analgesic effects of mefenamic acid . Unlike other NSAIDs, it appears to antagonize certain effects of existing prostaglandins through competition for prostaglandin binding sites.
Primary Characteristics
It is of Synthetic origin and belongs to Anthranilic Acid.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 296.1 · Solubility in Water: freely soluble · Solubility in Alcohol: soluble · Non-proprietary name: Meclofenamic Acid.
Pharmacokinetics
Distribution: Meclofenamic Acid has a plasma protein binding is 99 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 0.8-5.3 hr.
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Indications
Meclofenamic Acid is primarily indicated in conditions like Ankylosing spondylitis, Dysmenorrhoea, Osteoarthritis, Rheumatoid arthritis.
Contraindications
Meclofenamic Acid is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Meclofenamic Acid's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 6h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Meclofenamic Acid produces potentially life-threatening effects which include Renal failure. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Meclofenamic Acid are Oliguria, Agitation, Anuria, Agitation.
Meclofenamic Acid is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Diarrhea, Nausea.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)