Lormetazepam

Drug #906

Lormetazepam is a short-acting benzodiazepine with general properties similar to those of diazepam. Lormetazepam is used as a hypnotic in the short-term management of insomnia.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzodiazepine.

It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action. It is also classified under Sedatives and Hypnotics .

Molecular Weight: 335.2 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Lormetazepam.

Pharmacokinetics

Elimination: plasma half-life is 11hr.

Indications

Lormetazepam is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders.

Contraindications

Lormetazepam is contraindicated in conditions like Myasthenia gravis, Respiratory depression, Sleep apnea syndrome, Acute pulmonary insufficiency.

Dosage

Lormetazepam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 mg	1 mg	Every 24h	PO	Once at bed time
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lormetazepam is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Headache, Sleepiness.

Warnings / Precautions

Lormetazepam should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorder; avoid regular use during pregnancy (risk of neonatal withdrawl symptoms); use only if clear indication such as seizure control (high doses during late pregnancy or labour may cause neonatal hypothermia, hypotonia and respiratory depression); breast-feeding (present in milk, avoid if possible); reduce dose in elderly and debilitated, and in hepatic (avoid if severe) and renal impairment (start with small doses if severe); avoid prolong use (abrupt withdrawl thereafter); porphyria. It should not be used alone to treat depression (or anxiety associated with depression) or psychosis

Available Brands

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Single Ingredient

Tabs

1000 mcg

Storage Conditions

Lormetazepam should be stored Tab.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers

Manufacturers of Lormetazepam in Pakistan:

Atco Bayer Pacific