DrugInfoSys

Eperisone (HCl)

Drug #901

Chemically Eperisone (HCl) is identified as 4' -ethyl-2-methyl-3-piperidinopropiophenone hydrochloride. It exihibits both skeletal muscle relaxant and vasodilator properties because of its actions within the central nervous stem and on vascular smooth muscles. Eperisone (HCl) is used in the symptomatic treatment of muscle spasm.

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Primary Characteristics

It is of Synthetic origin and belongs to Piperidinopropiophenone.

It is classified in Anticholinergic Agent pharmacological group.

Molecular Weight: 295.8 · pKa: 9.6151 · Solubility in Water: freely soluble · Solubility in Alcohol: soluble · Non-proprietary name: Eperisone (HCl).

Molecular structure of Eperisone (HCl)

Pharmacokinetics

Distribution: Eperisone (HCl) has a volume of distribution is 3 L/Kg.

Elimination: it is metabolised via hepatic, plasma half-life is 1.6 - 1.8 hr, renal excretion is 77%.

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Indications

Eperisone (HCl) is primarily indicated in conditions like Muscular spasm, Spasticity.

Eperisone (HCl) is also indicated for secondary conditions like Musculoskeletal disorders.

Contraindications

Eperisone (HCl) is contraindicated in conditions like Hypersensitivity to the drug, Breast feeding.

Dosage

Eperisone (HCl)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
50 mg50 mgEvery 8hPO
Paediatric Dosage (20kg)
0 – 0——Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Eperisone (HCl) in overdosage may give rise to further complications which include Hepatic and Renal rysfunction, Urinary disoeders.

Eperisone (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anemia, Constipation , Diarrhea, Dizziness, Drowsiness, GI disturbance, Headache, Insomnia, Itching, Nausea and vomiting, Numbness , pruritis(less commonly), Rashes , Skin rashes, Sleepiness, Urinary retention, Weakness.

Warnings / Precautions

It should be used with caution in patients with a history of hypersensitivity to any drug product and patient with hepatic function disorders.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
50 mg

Storage Conditions

Eperisone (HCl) should be stored . .

Drug Classification

  1. 1.17.5 — Antispasmodics

Manufacturers

Manufacturers of Eperisone (HCl) in Pakistan:

BarrettGenomeGillmanHiltonKaizenWilshire