Enoxaparin
Enoxaparin is anticoagulant agent which has antithirombotic properties. Enoxaparin is a low molecular weight heparin fraction. Enoxaparin is prepared commercially from bovine lung and porcine intestinal mucosa.
Primary Characteristics
Enoxaparin is also known as enoxaparin sodium.
It is of Semisynthetic origin.
It is classified in Low Molecular Weight Heparin pharmacological group.
Molecular Weight: 3800 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Enoxaparin.
Pharmacokinetics
Distribution: Enoxaparin has a volume of distribution is 0.12l/kg.
Elimination: it is metabolised via liver, plasma half-life is 3.8(2.5-5.1)hr.
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Indications
Enoxaparin is primarily indicated in conditions like Ischaemic heart disease, Myocardial infarction, Prophylaxis of venous thromboembolism, Thrombosis, Treatment of deep vein thrombosis, Unstable angina.
Contraindications
Enoxaparin is contraindicated in conditions like Peptic ulcer, Hypersensitivity, Acute musculoskeletal disorders, Relief of sore throat, Initial treatment of acute conditions, Pain management, Acute pain (including pain following dental or orthopaedic surgery).
Dosage
Enoxaparin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 mg | 20 mg | Every 24h | SC | For 7-10 Days |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Enoxaparin produces potentially life-threatening effects which include Bleeding . Careful monitoring is needed with proper medical management.
Enoxaparin is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Anemia, Bleeding , Bruising, Confusion, Diarrhea, Erythema, Fever, Hypercalcemia, injection site pain, Nausea, Pruritus , Purpura, Thrombocytopenia.
Warnings / Precautions
Interference in Pathology
Enoxaparin may interfere in the diagnosis of Periodic blood count.
Available Brands
Storage Conditions
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators