Emedastine

Drug #898

Emedastine is a H1 histaminic receptor antagonist. Emedastine is used in eyes to reduce eye symptoms in hay fever.

Primary Characteristics

It is of Synthetic origin and belongs to Imidazole.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 534.6 · Solubility in Water: soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Emedastine.

Pharmacokinetics

Elimination: it is metabolised via liver, plasma half-life is 7 hour.

Indications

Emedastine is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis.

Contraindications

Emedastine is contraindicated in conditions like Renal impairment, Hepatic impairment.

Dosage

Emedastine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 – 2 mg	—	—	Ophthalmic	In 2 divided doses.
0.5 %	0.5 %	Every 12h	Ophthalmic
Paediatric Dosage (20kg)
0.05 5	0.05 5	Every 12h	Opthalmic	Do not use in children under 3 year of age.
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended under 3 yrs.

Drug Interactions

None recorded.

Side Effects

Emedastine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Edema, Headache, Irritation, Pain , Photophobia , Rhinitis .

Warnings / Precautions

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Emedastine should be used with caution in patients with liver impairment, dose should be reduce in patients with renal impairment. Avoid use in young children and use with caution in elderly patients. Topical preparation containing antihistamines should not be used on broken and eczematous skin. Don't wear contact leves if eye are red.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Eye Drops

0.05 %w/v

Storage Conditions

Emedastine should be stored Eye Drops, Soln.

Drug Classification

1.21.6 — Non-specific anticonjunctivitis preparations

Manufacturers

Manufacturers of Emedastine in Pakistan:

Novartis