Dipyrone
Also known as: Methampyrone, Metamizole, Analginum
Dipyrone is a pyrazolone analgesic and antipyretic drug, now seldom used because of its side effects. Dipyrone is NSAID (non-steroidal anti-inflammatory drug). Dipyrone is used in severe pain when no alternative is available
Primary Characteristics
Dipyrone is also known as Methampyrone, Metamizole, Analginum.
It is of Synthetic origin and belongs to Aminophenatone.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 351.4 · Solubility in Water: very soluble · Solubility in Alcohol: soluble · Non-proprietary name: Dipyrone.
Pharmacokinetics
Elimination: renal excretion is Major.
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Indications
Dipyrone is primarily indicated in conditions like Biliary colic, Genitourinary tract colic, Headache, Muscular spasm, Neoplasms, Pain, Refractory pyrexia, Rheumatic diseases, Toothache, Trauma.
Dipyrone is also indicated for secondary conditions like Surgery.
Contraindications
Dipyrone is contraindicated in conditions like G6pd deficiency, Hepatic porphyria.
Dosage
Dipyrone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.2 g | 1.2 g | Every 24h | IV/IM | |
| 0.5 – 4 mg | — | Every 6h | PO | daily individed doses. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dipyrone in overdosage may give rise to further complications which include Agranulocytosis , Blood dyscrasias , Shock .
Dipyrone is known to cause more or less tolerable side effects which are usually transient. These include Asthma, Pain at injection site, Rashes , Urticaria.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)