Benzylpenicillin (Na or K)

Also known as: Crystallin Penicillin G, Penicillin G

Drug #88

Benzylpenicillin (Na or K) is a BETA-LACTUM antibiotic and has a bactericidal action against gram-poisitve bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes, and actinomycetes. It exerts its killing action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis.Benzylpenicillin (Na or K) is used in treatment of a variety of infections including abscess, actinomycosis, anthrax, bites and stings, diptheria etc.

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Primary Characteristics

Benzylpenicillin (Na or K) is also known as Crystallin Penicillin G, Penicillin G.

It is of Semi Synthetic origin and belongs to Penicillin.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.

Molecular Weight: 356.4 · pK_a: 2.8 · Solubility in Water: very soluble · Solubility in Alcohol: soluble · Non-proprietary name: Benzylpenicillin (Na or K).

Molecular structure of Benzylpenicillin (Na or K)

Pharmacokinetics

Absorption: Benzylpenicillin (Na or K) has an oral bioavailability is 16% (±14%).

Distribution: Benzylpenicillin (Na or K) has a volume of distribution is 0.2-0.7 l/kg. plasma protein binding is 50-65%.

Elimination: it is metabolised via rapid by liver, plasma half-life is 0.8 hr, renal excretion is major.

Indications

Benzylpenicillin (Na or K) is primarily indicated in conditions like Bacterial endocarditis, Bacterial infections, Meningococcal disease, Muscle relaxation, Muscle relaxation for surgery or intubation, Penicillin sensitive infections.

Contraindications

None recorded.

Dosage

Benzylpenicillin (Na or K)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
128.57 mg/kg	128.57 mg/kg	Every 24h	IV	For 2-4 Weeks
Paediatric Dosage (20kg)
37.5 mg/kg	37.5 mg/kg	Every 6h	Intra Venous	-
Neonatal Dosage (3kg)
37.5 mg/kg	37.5 mg/kg	Every 6h	Intravenous

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Benzylpenicillin (Na or K) in overdosage may give rise to further complications which include Bone marrow hypoplasia , Cation intoxication , Convulsions , Hemolytic anemia , Hypersensitivity reactions , Jarisch herxheimer reaction , Renal damage .

Benzylpenicillin (Na or K) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.

Benzylpenicillin (Na or K) is known to cause more or less tolerable side effects which are usually transient. These include Local reactions, Skin rash.

Warnings / Precautions

Benzylpenicillin should be used with caution in patients with history of allergy, especially to drugs and in patient hypersensitive to penicillin. Care is necessary if very high dose of penicillin is given, especially if renal (kidney) function is poor. Renal and hematological status should be monitored during prolonged and high dose therapy.

Interference in Pathology

Benzylpenicillin (Na or K) may interfere in the diagnosis of Alter laboratory test values of 17-Hydroxycorticosteroids,glucose & 17-ketosteroids , Alter laboratory test values of 17-Ketogenic Steroids,PSP test,Thyroid Function Test. .

Available Brands

None recorded.

Storage Conditions

Benzylpenicillin (Na or K) should be stored Inj.

Drug Classification

1.6.2.1.1 — Penicillins