Cyclizine
Cyclizine is an H1 antihistaminic agent. Cyclizine is used as an antiemetic and anti-nauseant. Chemically Cyclizine is 1-(diphenylmethyl)-4-methylpiperazine. Cyclizine is effective to prevent or treat nausea, vomiting and dizziness caused by motion sickness. Cyclizine is administered intramuscularly. Abone statement is correct help but incorrect for its adminstrtion becaouse it is adminstered in oral drug and syrup form and IM through injection.
Primary Characteristics
Cyclizine is also known as Nausin, merzine, medizine.
It is of Synthetic origin and belongs to Piperazine.
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. It is also classified under Antiemetic/Antivertigo Agents .
Molecular Weight: 266.4 · Solubility in Water: 1 in 11000 · Solubility in Alcohol: 1 in 6 · Non-proprietary name: Cyclizine.
Pharmacokinetics
Elimination: plasma half-life is 20 hr, renal excretion is <1%.
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Indications
Cyclizine is primarily indicated in conditions like Motion sickness, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (palliative care), Vertigo, Vestibular disturbances.
Cyclizine is also indicated for secondary conditions like Menieres disease.
Contraindications
None recorded.
Dosage
Cyclizine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 8h | PO,IV,IM | |
| Paediatric Dosage (20kg) | ||||
| 2.5 mg/kg | 2.5 mg/kg | — | Oral | As Required |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not rcommended in this age goup | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cyclizine in overdosage may give rise to further complications which include Tardive dyskinesia , Neorologic effects.
Cyclizine produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome , Neuroleptic malignant syndrome. Careful monitoring is needed with proper medical management.
Cyclizine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Drowsiness, Dryness of mouth, Insomnia, Nervousness, Restlessness, Tachycardia, Urinary retensionX, Urticaria, Visual hallucinations.
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.7.1 — Acute migraine attack
- 2.17.2 — Antiemetics & antinauseants