Clioquinol
Clioquinol is an anti-amebic, antibacterial and anti-fungal agent with anti-eczematic and antipruritic properties. Clioquinol is administered orally, topically or intravaginally.
Primary Characteristics
Clioquinol is also known as Iodochllerohy droxygen.
It is of Synthetic origin and belongs to Idoquinoline.
It is classified in Antifungal Agent, Topical pharmacological group. It is also classified under Dermatological Products .
Molecular Weight: 305.5 · Solubility in Water: insoluble · Solubility in Alcohol: 1 in 3500 · Non-proprietary name: Clioquinol.
Pharmacokinetics
Absorption: Clioquinol has an oral bioavailability is 20% (±20%).
Elimination: it is metabolised via Hepatic, plasma half-life is 11-14 hr.
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Indications
Clioquinol is primarily indicated in conditions like Fungal infection, Ringworm, Skin infections, Tinea cruris, Tinea pedis.
Clioquinol is also indicated for secondary conditions like Otitis externa.
Contraindications
Clioquinol is contraindicated in conditions like Nail fungal infection, Infection of scalp.
Dosage
Clioquinol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3 % | 3 % | Every 12h | Topical | For not more than 7 days |
| Paediatric Dosage (20kg) | ||||
| 3 % | 3 % | Every 12h | Topical | For not more than 7 days |
| Neonatal Dosage (3kg) | ||||
| 3 % | 3 % | Every 12h | Topical | For not more than 7 days |
Drug Interactions
None recorded.
Side Effects
Clioquinol in overdosage may give rise to further complications which include Optic neuropathy , Peripheral neuropathy .
Clioquinol produces potentially life-threatening effects which include severe neurotoxicity. Careful monitoring is needed with proper medical management.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.3 — Antifungal drugs
- 2.6.4.1 — Antiamebic & antigiardiasis drugs
- 3.13.1 — Antifungals, topical
- 4.13.2.1 — Antibacterials, topical