Cefatrizine
Cefatrizine is a second generation semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefatrizine is used to treat a large variety of bacterial infections, such as respiratory tract, ear, skin and urinary tract infections. Cefatrizine is less effective against gram positive bacteria than first generation drugs. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefatrizine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Cephem Carboxylic Acid.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.
Molecular Weight: 462.5 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Cefatrizine.
Pharmacokinetics
None recorded.
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Indications
Cefatrizine is primarily indicated in conditions like Bone and joint infection, Bronchitis, Otitis media, Pharyngitis, Pneumonia, Skin infections, Tonsillitis, Urinary tract infection.
Contraindications
Cefatrizine is contraindicated in conditions like Hypersensitivity to the drug.
Dosage
Cefatrizine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 750 mg | 750 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| 15 mg/kg | 15 mg/kg | Every 12h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Cefatrizine in overdosage may give rise to further complications which include Bone marrow depression , Pseudomembranous colitis , Proteinuria , Hemolytic anemia .
Cefatrizine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Bleeding , Candidiasis , Chills, Diarrhea, Dizziness, Dyspnea, Paresthesias, Skin rashes, Urticaria, Vaginitis.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins