Cefadroxil

Drug #840

Cefadroxil is a first generation semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefadroxil is very active against gram positive cocci. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefadroxil is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Cephem Carboxylic Acid.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.

Molecular Weight: 381.4 · Solubility in Water: soluble · Solubility in Alcohol: slightly · Non-proprietary name: Cefadroxil.

Pharmacokinetics

Distribution: Cefadroxil has a plasma protein binding is 20%.

Elimination: plasma half-life is 1.5 hr, renal excretion is 90%.

Indications

Cefadroxil is primarily indicated in conditions like Arrhythmias after myocardial infarction, As an antidote to organophosphorous (insecticides) poisoning, Pharyngitis, Respiratory tract infections, Skin infections, Tonsillitis, Urinary tract infection.

Contraindications

None recorded.

Dosage

Cefadroxil's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
750 mg	750 mg	Every 8h	PO
Paediatric Dosage (20kg)
12.5 mg/kg	12.5 mg/kg	Every 12h	Oral	-
Neonatal Dosage (3kg)
12.5 mg/kg	12.5 mg/kg	Every 12h	Oral	-

Drug Interactions

None recorded.

Side Effects

Cefadroxil is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Bleeding , Chills, Dermatitis, Diarrhea, Dizziness, Fever, Glossitis, Paresthesias, Urticaria, Vaginitis.

Warnings / Precautions

Cefadroxil should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

Available Brands

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Single Ingredient

Caps

1 g 20 mg 250 mg 400 mg 500 mg

Drops

100 mg 100 mg/ml

Dry Susp

125 mg/5ml 250 mg/5ml

Oral Soln

100 mg/5ml

Susp

100 mg/5ml 200 mg/5ml 250 mg/5ml

Susp

125 mg/5ml

Tabs

1 g 500 mg

Storage Conditions

Cefadroxil should be stored Oral Susp (reconstituted). Tab, Caps, Dry Powder for Susp.

Drug Classification

1.6.2.1.3 — Cephalosporins