Benzalkonium (Cl)
Benzalkonium (Cl) is a mixture of alkylbenzyl dimethylammonium chloride. Benzalkonium (Cl) is a rapidly acting surface disinfectant, antiseptic and detergent active against both gram negative and gram positive bacterias and certain viruses, fungi, yeasts and protozoa. Benzalkonium (Cl) is applied topically to the skin and mucous membranes. But recently Benzalkonium (Cl) is recommended that it should not be used as a antiseptic on skin because outbreak of infections have occurred due to bacterial growth.
Primary Characteristics
It is of Synthetic origin and belongs to Benzylammonium salt .
It belongs to Dermatological-Antiseptic pharmacological group on the basis of mechanism of action.
Molecular Weight: 339.5 · pKa: · Solubility in Water: very soluble · Solubility in Alcohol: very soluble · Non-proprietary name: Benzalkonium chloride.
Pharmacokinetics
Distribution: Benzalkonium (Cl) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Benzalkonium (Cl) is primarily indicated in conditions like Bladder irrigation, Ear,eye,nose and throat irrigation, Gingivitis, Perodontal diseases, Preoperative disinfection of unbroken skin, Stomatitis, Thrush, Tonsillitis, Urethral irrigation.
Benzalkonium (Cl) is also indicated for secondary conditions like Burns, Wounds.
Contraindications
Benzalkonium (Cl) is contraindicated in conditions like Hypersensitivity.
Dosage
Benzalkonium (Cl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.01 % | 0.01 % | — | Ophthalmic | drops. As required. |
| 0.15 % | 0.15 % | — | Topical | As Required |
| Paediatric Dosage (20kg) | ||||
| 0.15 % | 0.15 % | — | Topical | As Required |
| Neonatal Dosage (3kg) | ||||
| 0.15 % | 0.15 % | — | Topical | As Required |
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Benzalkonium (Cl) are Vomiting, Coma, Collapse, Death , Convulsions , Muscular weakness, Restlessness , Cyanosis, Dyspnea, Apprehension , Paralysis of respiratory muscle .
Benzalkonium (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Allergic contact dermatitis .
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.8 — Stomatologicals and dentifrices
- 2.21.7 — Other ophthalmologicals
- 3.25.5 — Pharyngeal preparations