Butoconazole (Nitrate)

Drug #827

Butoconazole (Nitrate) is imidazole anti-fungal agent and is used to treat vaginal fungal infections.

Primary Characteristics

It is of Synthetic origin and belongs to Imidazole.

It is classified in Antifungal Agent, Vaginal pharmacological group.

Molecular Weight: 474.8 · Solubility in Water: insoluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Butoconazole (Nitrate).

Molecular structure of Butoconazole (Nitrate)

Pharmacokinetics

Absorption: Butoconazole (Nitrate) has an oral bioavailability is 1.75% (±0.45%).

Elimination: plasma half-life is 21 - 24 hr.

Indications

Butoconazole (Nitrate) is primarily indicated in conditions like Bacterial infections, Vulvo-vaginal mycotic infection.

Contraindications

Butoconazole (Nitrate) is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Butoconazole (Nitrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 %	2 %	Every 24h	Intra Vaginal	At bed time, for 3 days.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Butoconazole (Nitrate) in overdosage may give rise to further complications which include Thrombocytopenia .

Butoconazole (Nitrate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Irritation, Itchy fingers, Soreness , Swelling , Vaginal burning, Vulvular itching.

Warnings / Precautions

Butoconazole should be used cautiously during pregnancy or lactation only if clearly needed.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Cream

2 % w/w

Storage Conditions

Butoconazole (Nitrate) should be stored Cream.

Drug Classification

1.22.2 — Gynecological anti-infectives

Manufacturers

Manufacturers of Butoconazole (Nitrate) in Pakistan:

Valor