Buflomedil (HCl)

Drug #826

Buflomedil (HCl) is a vasodilator (relaxes the blood vessels). Buflomedil (HCl) is used in the treatment of cerebro-vascular and peripheral vascular diseases.

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Primary Characteristics

It is of Synthetic origin and belongs to Pyrolidine.

It belongs to Platelet Aggregation Inhibitor pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.

Molecular Weight: 343.8 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Buflomedil (HCl).

Pharmacokinetics

Distribution: Buflomedil (HCl) has a plasma protein binding is 60 - 80%.

Elimination: it is metabolised via hepatic, plasma half-life is 1.91 - 3.65 hr, renal excretion is 10 - 28%.

Indications

Buflomedil (HCl) is primarily indicated in conditions like Dementia, Disorientation, Insomnia, Intermittant claudication, Ischaemic rest pain, Loss of concentration, Loss of memory, Raynaud's syndrome, Skin ulceration, Tinnitus, Trophic disorders, Vertigo.

Contraindications

Buflomedil (HCl) is contraindicated in conditions like Arterial hemorrhage.

Dosage

Buflomedil (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 mg	50 mg	Every 12h	IM	For 14-Days
75 mg	75 mg	Every 12h	IV
225 mg	225 mg	Every 12h	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

The signs and symptoms that are produced after acute overdosage of Buflomedil (HCl) are Tachycardia , Hypotension, Convulsions .

Buflomedil (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, GI disturbance, Headache, Nausea, Vasodilation , VertigoX.

Warnings / Precautions

Buflomedil (betablocker) should not be given to patients with bronchospasm, asthma, with history of obstructive airway disease, metabolic acidosis, partial heart block, sinus bradycardia or psoriasis. The dose may need to reduce in patients with renal (kidney) or hepatic (liver) dysfunction. Patients with long term treatment with betablockers should have their medication discontinued gradually over a period of 1 to 2 weeks, because it may result in angina, myocardial infraction (MI), ventricular arrhythmia or death. This drug should be used only if clearly needed during pregnancy or lactation.

Available Brands

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Single Ingredient

Tabs

150 mg 300 mg

Storage Conditions

Buflomedil (HCl) should be stored Tabs.

Drug Classification

1.12.8 — Other cardiovascular preparations
2.24.6 — Cerebrovascular drugs

Manufacturers

Manufacturers of Buflomedil (HCl) in Pakistan:

Indus