Benzocaine

Drug #815

Benzocaine is a weak local anaesthetic similar to lignocain, used in proprietary preparations for sore throat. Benzocaine is insoluble ester type local anesthetic. It consist of an aromatic ring connected by an intermediate chain to an ionizable group, usually a tertiary amine. Applied topically to the skin and mucous membranes.

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Primary Characteristics

It is of Synthetic origin and belongs to Ester type.

It is classified in Local Anesthetics pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 165.2 · Solubility in Water: 1 in 2500 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Benzocaine.

Pharmacokinetics

Elimination: it is metabolised via Partially Hepatic, renal excretion is major.

Indications

Benzocaine is primarily indicated in conditions like Abrasion, Burns, Canker sores, Insect bites, Otitis externa, Otitis media, Pruritus, Rectal fissures, Rectal pain, Sore throat, Toothache.

Contraindications

Benzocaine is contraindicated in conditions like Bacterial infections, Opthalmologic anaesthesia.

Dosage

Benzocaine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.25 mg	2.25 mg	Every 8h	Ear
Paediatric Dosage (20kg)
2.25 mg	2.25 mg	Every 8h	Ear	-
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Benzocaine in overdosage may give rise to further complications which include Angioedema , Sinus bradycardia , Sinus tachycardia , Seizures , Methemoglobinemia .

Benzocaine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Burning, Contact dermatitis, Dizziness, Drowsiness, Edema, Headache, Photosensitivity, Restlessness, Stinging on application, Tenderness , Tremor, Urethritis, Urticaria.

Warnings / Precautions

Avoid continuous use for longer than 3 months. Avoid use in patient with known hypersensitivity. It should be given with caution to the elderly, to debilitate, to children, patients with epilepsy, impaired cardiac conduction or respiratory function, shock or liver damage. It might be ototoxic and should not be instilled into the middle ear. The application of local anesthetics to the skin for prolonged period or to the extensive area should be avoided.

Available Brands

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Multi-Ingredient Combinations

Ear Drops

1 %w/v

Lozenges

5 mg

Storage Conditions

Benzocaine should be stored Lozenges. Skin Oint, Cream, Mouth Gel, Oint or Soln, Ear Soln, Aerosol.

Drug Classification

1.1.2 — Local anesthetics
2.28 — Otic drugs

Manufacturers

Manufacturers of Benzocaine in Pakistan:

Highnoon Reko Scotmann