Amino Acids
Amino Acids are any organic compound containing an amino (-NH2) and a carboxyl (-COOH) group. Amino Acids are of two type; essential and non-essential it. Essential Amino Acids can not be synthesized by body in sufficient amounts and must therefore be present in food. Esssential Amino Acids are also known as indispensible it. Amino Acids are source of protein and nitrogen in body to prevent tissue or muscle breakdown or damage and as a dietary supplement for those individuals unable to eat enough or proper quantity of amino acid because of disease or surgery. <br>Gamma-aminobutyric acid / (GABA) (-aminobutyric acid) the principal inhibitory neurotransmitter in the brain but also occurring in several extraneural tissues, including kidney and pancreatic islet gamma cells. Released from presynaptic cells upon depolarization, it modulates membrane chloride permeability and inhibits postsynaptic cell firing. <br>Gamma-Amino-Beta-Hydroxybutyric Acid (GABOB) a hydroxy-derivative of gamma-Aminobutyric acid (GABA), is normally found in human and animal cerebral tissues.
Primary Characteristics
Amino Acids is also known as Gamma Amino ß Hydroxybutyric Acid , Gamma Aminobutyric Acid.
It is of Natural origin and belongs to L-Amino acid.
It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action.
Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Amino Acids · pH: 6.2.
Pharmacokinetics
None recorded.
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Indications
Amino Acids is primarily indicated in conditions like Homocystinuria, Infections, Malnutrition, Negative nitrogen balance, Phenylketonuria, Severe burns, Trauma.
Contraindications
Amino Acids is contraindicated in conditions like Renal impairment, Hepatic impairment, Breast feeding.
Dosage
Amino Acids's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7.5 % | 7.5 % | Every 24h | IV Inf | |
| 500 ml | 500 ml | Every 24h | IV Inf | Over 4-6 hrs. at the rate of 30-40 drops/min. |
| Paediatric Dosage (20kg) | ||||
| 1.75 mg/kg | 1.75 mg/kg | Every 24h | Intra Venous | As Required |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Amino Acids in overdosage may give rise to further complications which include Hepatic damage , Acute folic acid deficiency , Metabolic complications.
Amino Acids produces potentially life-threatening effects which include Hyperchloremic acidosis. Careful monitoring is needed with proper medical management.
Amino Acids is known to cause more or less tolerable side effects which are usually transient. These include Chills, Fever, Flushing, Sweating , Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.26.2.4 — Amino acid solutions
Manufacturers
Manufacturers of Amino Acids in Pakistan: