Almitrine

Drug #790

Almitrine is used as a respiratory stimulant in acute respiratory failure such as chronic obstructive pulmonary disease.

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Primary Characteristics

It is of Synthetic origin and belongs to Methanesulfonate.

It is classified in Vasotherapeutics pharmacological group.

Molecular Weight: 669.8 · pK_a: 4, 5 · Solubility in Water: insoluble · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Almitrine.

Pharmacokinetics

Absorption: Almitrine has an oral bioavailability is 93% (±3%), pre-systemic (first-pass) metabolism accounts for 20% (±10%).

Distribution: Almitrine has a volume of distribution is > 40 l/kg. plasma protein binding is 99.5%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 20-30 days, renal excretion is 12-15%.

Indications

Almitrine is primarily indicated in conditions like Acute exacerbation of hypoxic coadaptation, Chronic respiratory failure in hypoxic load, Respiratory depression after anesthesia, Respiratory depression after drug overdose.

Contraindications

Almitrine is contraindicated in conditions like Hepatic failure, Restrictive lung disease, Primary heart disease.

Dosage

Almitrine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3 mg/kg	3 mg/kg	—	IV Inf	Infuse over 2 hours, give in 2-3 div.doses.
37.5 mg/day	37.5 mg/day	—	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Almitrine in overdosage may give rise to further complications which include Peripheral neuropathy .

The signs and symptoms that are produced after acute overdosage of Almitrine are Hyperventilation, Hypocapnia.

Almitrine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Burning, Drowsiness, Dyspnea, Epigastric pain, GI disturbance, Heaviness, Increased intracranial pressure, Insomnia, Irritability, Nausea, Palpitation, Vertigo, Weight LossX.

Warnings / Precautions

Almitrine should be used with caution in patient with hepatic disease. The best mean of achieving and maintaining therapeutic levels without toxic accumulation is by intrmittent dosing, this avoid the accumulation of drug on continuous dosing.

Available Brands

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Multi-Ingredient Combinations

Tabs

30 mg

Storage Conditions

Almitrine should be stored Tab, Vial.

Drug Classification

1.25.6 — Respiratory stimulants and pulmonary surfactants

Manufacturers

Manufacturers of Almitrine in Pakistan:

Servier