Aminoglutethimide
Aminoglutethimide is antineoplastic agent, also called as anticancer drug. Aminoglutethimide is effective in the treatment of breast cancers to slow or stop the growth of abnormal cells. Aminoglutethimide is used in combination of different anticancer drugs to obtain most excellent therapeutic effects and minimize unwanted effects or toxicities.
Primary Characteristics
It is of Synthetic origin and belongs to Ethylpiperidine.
It belongs to Steroid 20-a-hydroxylase inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 232.3 · Solubility in Water: >1 in 10000 · Solubility in Alcohol: >1 in 10 · Non-proprietary name: Aminoglutethimide.
Pharmacokinetics
Absorption: Aminoglutethimide has an oral bioavailability is 100%.
Distribution: Aminoglutethimide has a volume of distribution is 1.3 l/kg. plasma protein binding is 23%.
Elimination: plasma half-life is 15.5 hr, renal excretion is 50% (unchanged).
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Indications
Aminoglutethimide is primarily indicated in conditions like Advanced breast or prostate cancer, Breast cancer, Cushing`s syndrome due to malignant disease, Cushing's syndrome, Prostatic cancer.
Contraindications
Aminoglutethimide is contraindicated in conditions like Adrenal insufficiency, Porphyria, Pregnancy, Breast feeding.
Dosage
Aminoglutethimide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4.762 mg/kg | 4.762 mg/kg | Every 8h | PO | - |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Aminoglutethimide in overdosage may give rise to further complications which include Agranulocytosis , Pancytopenia .
Aminoglutethimide produces potentially life-threatening effects which include Adrenal Insufficiency . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Aminoglutethimide are Drowsiness.
Aminoglutethimide is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Giddiness, Lethargy, Rashes , Skin rashesX.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.8.3 — Hormones and antihormones