Zuclopenthixol
Zuclopenthixol is a tranquillizer, similar to chlorpromazine. Zuclopenthixol is used in the treatment of schizophrenia.
Primary Characteristics
It is of Synthetic origin and belongs to Xanthine.
It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Thioxenthene pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 473.9 · pKa: 3.4, 6.1 · Solubility in Water: high · Solubility in Alcohol: slight · Non-proprietary name: Zuclopenthixol.
Pharmacokinetics
Absorption: Zuclopenthixol has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 44%.
Distribution: Zuclopenthixol has a volume of distribution is 20 l/kg. plasma protein binding is 98 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 13 - 23 hr, renal excretion is 10 - 20 %.
Advertisement
Indications
Zuclopenthixol is primarily indicated in conditions like Dementia, Enhance permeation of SC or IM inj, Labyrinthine disorders, Mania, Prolactinoma, Psychosis, Schizophrenia, Second trimester abortion.
Contraindications
Zuclopenthixol is contraindicated in conditions like Alcohol dependence, Parkinsonism, Phaeochromocytoma, Coma, CNS depression.
Dosage
Zuclopenthixol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 300 mg | 300 mg | — | IM | Every 2-4 Week |
| 25 mg | 25 mg | Every 24h | PO | Initial |
| 35 mg | 35 mg | Every 8h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Zuclopenthixol produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome , Fever , Hypertonicity . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Zuclopenthixol are Coma, Hypothermia, Convulsions , Somnolence, Extrapyramidal effects .
Zuclopenthixol is known to cause more or less tolerable side effects which are usually transient. These include Akathisia, Benign leucopenia, Dystonic reactions, Loss of libido, Menstrual irregularity, Orthostatic hypotension, Parkinsonism, Tachycardia, Tardive dyskinesia.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders