Zopiclone

Drug #763

Zopiclone is a non-benzodiazipine hypnotic. Zopiclone is used for short term treatment of insomnia (sleeping disorders).

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Primary Characteristics

It is of Synthetic origin and belongs to Cyclopyrolones.

It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 388.8 · pK_a: 6.7 · Solubility in Water: Insoluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Zopiclone.

Pharmacokinetics

Absorption: Zopiclone has an oral bioavailability is 96.5% (±1.5%).

Distribution: Zopiclone has a volume of distribution is 100 litre. plasma protein binding is 45 %.

Elimination: plasma half-life is 3.5 - 6 hr, renal excretion is 4 - 5 %.

Indications

Zopiclone is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders.

Contraindications

Zopiclone is contraindicated in conditions like Respiratory insufficiency.

Dosage

Zopiclone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.17 mg/kg	0.17 mg/kg	Every 24h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown6 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Zopiclone are Drowsiness, Ataxia, Lethargy.

Zopiclone is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Depressive moods, Irritability.

Warnings / Precautions

Perform periodic blood counts and liver function tests during long term therapy. Zopiclone should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma). Avoid use in patients with severe hepatic (liver) insufficiency.

Available Brands

None recorded.

Storage Conditions

Zopiclone should be stored Tab.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders