Xylometazoline (HCl)
Chemically Xylometazoline (HCl) is 2-(4-tert-butyl-2, 6-dimethylbenzyl)-2-imidazoline. Xylometazoline (HCl) is a direct acting alpha-adrenoceptor agonist, used as vasoconstrictor for nasal decongestion. It promotes nasal drainage and relieves nasal stuffiness. Xylometazoline (HCl) is used to relieve symptoms associated with a cold, hay fever, allergies, sinus infections and other related conditions.
Primary Characteristics
Xylometazoline (HCl) is also known as Xylometazoline .
It is of Synthetic origin and belongs to Imidazole .
It belongs to Alpha-2 adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Opthalmic Agent, Vasoconstrictor pharmacological group. It is also classified under Nasal Decongestants .
Molecular Weight: 280.8 · pKa: · Solubility in Water: 1 in 12 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Xylometazoline HCl · pH: 5 · Isotonic value: 4.68.
Pharmacokinetics
Distribution: Xylometazoline (HCl) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Xylometazoline (HCl) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Eye inflammation, Nasal congestion, Ocular congestion, Otitis media, Sinusitis.
Contraindications
Xylometazoline (HCl) is contraindicated in conditions like Diabetes mellitus, Hypertension, Narrow-angle glaucoma, Vasomotor rhinitis, Atrophic rhinitis.
Dosage
Xylometazoline (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.1 % | 0.1 % | Every 8h | Intra Nasal | 2-3 drops in each nostril. |
| Paediatric Dosage (20kg) | ||||
| 0.125 mg | 0.125 mg | Every 8h | Opthalmic | - |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Xylometazoline (HCl) in overdosage may give rise to further complications which include Rhinitis medicamentosa .
Xylometazoline (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Dryness of eye, Dryness of nose, Headache, Stinging on application.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.25.4 — Nasal preparations