Beclomethasone (Dipropionate)
Also known as: Beclometasone (Dipropionate), Beclomethasone
Beclomethasone is a synthetic halogenated inhaled glucocorticoid. Beclomethasone (Dipropionate) is used for treating steroid-dependent asthma, for relieving symptoms associated with allergic or nonallergic (vasomotor) rhinitis or for preventing recurrent nasal polyps following surgical removal. It has 500 times the topical anti-infammatory activity of dexamethasone but Beclomethasone (Dipropionate) is less active as a systemic glucocorticoid and is almost inactive by the oral route.
Primary Characteristics
Beclomethasone (Dipropionate) is also known as Beclometasone (Dipropionate), Beclomethasone .
It is of Synthetic origin and belongs to Steroid.
It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Nasal pharmacological group.
Molecular Weight: 521 · pKa: unionized · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 60 · Non-proprietary name: Beclomethasone (Dipropionate).

Pharmacokinetics
Distribution: Beclomethasone (Dipropionate) has a plasma protein binding is 87%.
Elimination: it is metabolised via Extensive by liver, plasma half-life is 3 hr (Initial), 15 hr (terminal), renal excretion is 15%.
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Indications
Beclomethasone (Dipropionate) is primarily indicated in conditions like Allergic rhinitis, Asthma, Dermatitis, Eczema, Granuloma annulare, Lichen planus, Lichen simplex, Lupus erythematosus, NSAID-associated gastric and duodenal ulcers (prophylaxis), Prophylaxis of asthma, Pruritus ANI, Psoriasis, Vasomotor rhinitis.
Beclomethasone (Dipropionate) is also indicated for secondary conditions like Liver transplant.
Contraindications
Beclomethasone (Dipropionate) is contraindicated in conditions like Acne, Respiratory tract infections, Pulmonary TB, Ulcers, Rosacea, Perioral dermatitis.
Dosage
Beclomethasone (Dipropionate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 375 mcg | 375 mcg | Every 12h | Inhalation | Frequency may be increased upto 4 times/day if needed. |
| Paediatric Dosage (20kg) | ||||
| 7.5 ug/kg | 7.5 ug/kg | Every 8h | Inhalation | - |
| Neonatal Dosage (3kg) | ||||
| 6.25 ug/kg | 6.25 ug/kg | Every 8h | Inhalation | |
| 0.1 % | 0.1 % | — | topical | As required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Beclomethasone (Dipropionate) in overdosage may give rise to further complications which include Increased IOP (intraocular pressure), Striae , Glaucoma , Osteoporosis , Dermal thinning , Telangiectasia, Cataract.
Beclomethasone (Dipropionate) produces potentially life-threatening effects which include Addisonian crises, Cushing`s syndrome. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Beclomethasone (Dipropionate) are Hallucinations .
Beclomethasone (Dipropionate) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Dysgeusia, Dysphonia, Epithelial damage, Flushing, Irritation, Nasal irritation, Oropharyngeal candidiasis, Sneezing, Urticaria, Xerostomia .
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.13.3.2 — Corticosteroids combinations
- 2.25.1.2 — Inhalants
- 3.25.4 — Nasal preparations