DrugInfoSys

Beclomethasone (Dipropionate)

Also known as: Beclometasone (Dipropionate), Beclomethasone

Drug #76

Beclomethasone is a synthetic halogenated inhaled glucocorticoid. Beclomethasone (Dipropionate) is used for treating steroid-dependent asthma, for relieving symptoms associated with allergic or nonallergic (vasomotor) rhinitis or for preventing recurrent nasal polyps following surgical removal. It has 500 times the topical anti-infammatory activity of dexamethasone but Beclomethasone (Dipropionate) is less active as a systemic glucocorticoid and is almost inactive by the oral route.

Primary Characteristics

Beclomethasone (Dipropionate) is also known as Beclometasone (Dipropionate), Beclomethasone .

It is of Synthetic origin and belongs to Steroid.

It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Nasal pharmacological group.

Molecular Weight: 521 · pKa: unionized · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 60 · Non-proprietary name: Beclomethasone (Dipropionate).

Molecular structure of Beclomethasone (Dipropionate)

Pharmacokinetics

Distribution: Beclomethasone (Dipropionate) has a plasma protein binding is 87%.

Elimination: it is metabolised via Extensive by liver, plasma half-life is 3 hr (Initial), 15 hr (terminal), renal excretion is 15%.

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Indications

Beclomethasone (Dipropionate) is primarily indicated in conditions like Allergic rhinitis, Asthma, Dermatitis, Eczema, Granuloma annulare, Lichen planus, Lichen simplex, Lupus erythematosus, NSAID-associated gastric and duodenal ulcers (prophylaxis), Prophylaxis of asthma, Pruritus ANI, Psoriasis, Vasomotor rhinitis.

Beclomethasone (Dipropionate) is also indicated for secondary conditions like Liver transplant.

Contraindications

Beclomethasone (Dipropionate) is contraindicated in conditions like Acne, Respiratory tract infections, Pulmonary TB, Ulcers, Rosacea, Perioral dermatitis.

Dosage

Beclomethasone (Dipropionate)'s dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
375 mcg375 mcgEvery 12hInhalationFrequency may be increased upto 4 times/day if needed.
Paediatric Dosage (20kg)
7.5 ug/kg7.5 ug/kgEvery 8hInhalation-
Neonatal Dosage (3kg)
6.25 ug/kg6.25 ug/kgEvery 8hInhalation
0.1 %0.1 %topicalAs required

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Beclomethasone (Dipropionate) in overdosage may give rise to further complications which include Increased IOP (intraocular pressure), Striae , Glaucoma , Osteoporosis , Dermal thinning , Telangiectasia, Cataract.

Beclomethasone (Dipropionate) produces potentially life-threatening effects which include Addisonian crises, Cushing`s syndrome. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Beclomethasone (Dipropionate) are Hallucinations .

Beclomethasone (Dipropionate) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Dysgeusia, Dysphonia, Epithelial damage, Flushing, Irritation, Nasal irritation, Oropharyngeal candidiasis, Sneezing, Urticaria, Xerostomia .

Warnings / Precautions

Beclomethasone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.

Available Brands

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Multi-Ingredient Combinations

Storage Conditions

Beclomethasone (Dipropionate) should be stored Nasal Spray, Inhaler.

Drug Classification

  1. 1.13.3.2Corticosteroids combinations
  2. 2.25.1.2Inhalants
  3. 3.25.4Nasal preparations

Manufacturers

Manufacturers of Beclomethasone (Dipropionate) in Pakistan: