Tinidazole

Drug #720

Tinidazole is antimicrobial agent. Tinidazole is used for prevention of post-operative anaerobic and acute gum infections.

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Primary Characteristics

It belongs to Imidazole.

It belongs to Antibiotic (Prokaryote DNA) pharmacological group on the basis of mechanism of action and also classified in Amebicides pharmacological group.

Molecular Weight: 247 · pK_a: 1.81 · Non-proprietary name: Tinidazole.

Pharmacokinetics

Absorption: Tinidazole has an oral bioavailability is 100%.

Distribution: Tinidazole has a volume of distribution is 0.641 l/kg. plasma protein binding is 12 %.

Elimination: plasma half-life is 12 - 14 hr.

Indications

Tinidazole is primarily indicated in conditions like Abdominal surgery prophylaxis, Acute leukemia, Amoebiasis, Anaerobic infections, Giardiasis, NSAID-associated ulceration, Prophylaxis of acid aspiration in obstetric patients, Trichomoniasis, Upper gastro-intestinal and breast cancer.

Contraindications

None recorded.

Dosage

Tinidazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 g	2 g	Every 24h	PO	Initial dose.
1000 mg	1000 mg	Every 24h	PO	For 5-7 days.
Paediatric Dosage (20kg)
62.5 mg/kg	62.5 mg/kg	Every 24h	Oral	-
Neonatal Dosage (3kg)
62.5 mg/kg	62.5 mg/kg	Every 24h	Oral

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tinidazole produces potentially life-threatening effects which include Hypotension, Bronchospasm , Dyspnea, Facial edema, Laryngeal edema. Careful monitoring is needed with proper medical management.

Tinidazole is known to cause more or less tolerable side effects which are usually transient. These include Headache, Metallic taste, Nausea, Thrombophlebitis , Urticaria, Vomiting .

Warnings / Precautions

Tinidazol should be used with caution in patients with any allergy. Avoid use during pregnancy or lactation. Avoid alcoholic beverages while taking this medication as severe stomach upset, nausea, vomiting, headache and flushing can occur.

Interference in Pathology

Tinidazole may interfere in the diagnosis of Interferes with determinations of AST,SGOT, Interferes with determinations of ALT,SGPT.

Available Brands

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Single Ingredient

Tabs

1 g 300 mg 500 mg

Multi-Ingredient Combinations

Vag Tabs

200 mg

Storage Conditions

Tinidazole should be stored Tab.

Drug Classification

1.6.4.1 — Antiamebic & antigiardiasis drugs

Manufacturers

Manufacturers of Tinidazole in Pakistan:

Chiesi Highnoon Pfizer Pharmawise Platinum