DrugInfoSys

Bacitracin

Drug #72

Bacitracin is an antibacterial ploypeptide produced by the growth of a gram positive, spore forming organism belonging to the licheniformis group of Bacillus subtilis. Bacitracin is active against many gram positive bacteria such as staphylococci, streptococci and pneumococci and some gram negative bacteria. Bacitracin is applied topically to the skin or conjunctivita or administered by intramuscular injection in the treatment of infections caused by susceptible organisms

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Primary Characteristics

Bacitracin is also known as Bacitracin zinc.

It is of Semi Synthetic origin and belongs to Peptide Bacitracin.

It belongs to Antibiotic (Cell Wall) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 1411 · Solubility in Water: freely soluble · Solubility in Alcohol: high · Non-proprietary name: Bacitracin.

Molecular structure of Bacitracin

Pharmacokinetics

Elimination: renal excretion is 10-40%.

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Indications

Bacitracin is primarily indicated in conditions like Bacterial infections, Pseudomembranous colitis, Superficial infections.

Contraindications

Bacitracin is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Bacitracin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
12500 IU/g12500 IU/gEvery 8hTopical -
Paediatric Dosage (20kg)
12500 IU/g12500 IU/gEvery 8hTopical -
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Bacitracin produces potentially life-threatening effects which include Nephrotoxicity, Hypersensitivity . Careful monitoring is needed with proper medical management.

Bacitracin is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Azotemia, Blurred vision, Diarrhea, Hypotension , Nausea, Vomiting .

Warnings / Precautions

Take appropriate measures in case of secondary infections. Maintain adequate fluid intake while taken bacitracin. Carefully determine renal function before initiating therapy. If renal toxicity occurs, discontinue use.

Available Brands

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Multi-Ingredient Combinations

Aerosol
12500 IU
Cream
250 IU/g
Eye Oint
400 IU/g500 IU/g
Oint
500 IU/g
Powder
250 IU/g500 IU/g

Storage Conditions

Bacitracin should be stored Dry Powder for Inj. Inj (reconstituted soln). Skin Oint, Cream, Eye Oint.

Drug Classification

  1. 1.13.2.1 — Antibacterials, topical

Manufacturers