Thioridazine (HCl)

Drug #714

Thioridazine (HCl) is a phenothiazine, similar to chlorpromazine. Thioridazine (HCl) is used in the treatment of certain mental disorders such as psychosis, confusion and agitation.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenothiazine.

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 407 · pK_a: 9.5 · Solubility in Water: 1 in 9 · Solubility in Alcohol: 1 in 6 - 10 · Non-proprietary name: Thioridazine (HCl).

Molecular structure of Thioridazine (HCl)

Pharmacokinetics

Absorption: Thioridazine (HCl) has an oral bioavailability is 67.5% (±7.5%).

Distribution: Thioridazine (HCl) has a volume of distribution is 10 l/kg. plasma protein binding is 96.5 - 99.3 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 16 - 36 hr, renal excretion is < 10 %.

Indications

Thioridazine (HCl) is primarily indicated in conditions like Anxiety, Hypomania, Mania, Psychosis, Schizophrenia.

Thioridazine (HCl) is also indicated for secondary conditions like Epilepsy, Schizophrenia and other psychoses.

Contraindications

Thioridazine (HCl) is contraindicated in conditions like Blood dyscrasias, Coma, Cardiovascular disease, CNS depression.

Dosage

Thioridazine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
175 mg	175 mg	Every 24h	PO	For psychotic out patients.
350 mg	350 mg	Every 24h	PO	For hospitalized psychotic patients.
Paediatric Dosage (20kg)
1.25 mg/kg	1.25 mg/kg	Every 12h	Oral	-
Neonatal Dosage (3kg)
0.5 mg/kg	0.5 mg/kg	Every 12h	Oral

Drug Interactions

Unknown11 interactions

3 interactions

Major4 interactions

Moderate6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Thioridazine (HCl) in overdosage may give rise to further complications which include Acute dyskinesia , Pigmentory retinopathy , Tardive dyskinesia .

Thioridazine (HCl) produces potentially life-threatening effects which include Agranulocytosis, Arrhythmias, Neuroleptic Malignant Syndrome , Cardiac Arrest . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Thioridazine (HCl) are Coma, Cardiac arrhythmias, Shallow breathing, Loss of reflexes, Hyperflexia , Hypotension, Epileptic seizures, Motor restlessness.

Thioridazine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Drowsiness, Dry mouth, Nasal congestion , Postural hypotension, Sedation , Sexual dysfunction, Tachycardia, Termors, Urinary retensionX.

Warnings / Precautions

Thioridazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal (kidney) impairment, prostatic hypertrophy. Photosensitization may occur, caution patients against exposure to sunlight or UV light. Discontinue use atleast 48 hr before myelography.

Interference in Pathology

Thioridazine (HCl) may interfere in the diagnosis of Frings method for measuring urinary Alkaloids and Barbiturates , Trindes Method for measuring Urinary Salicylate , Urinary Tests for Pregnancy .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Susp

10 mg/5ml

Tabs

10 mg 100 mg 25 mg

Storage Conditions

Thioridazine (HCl) should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders

Manufacturers

Manufacturers of Thioridazine (HCl) in Pakistan:

Novartis