Thiopentone (Na)
Also known as: Thiopental
Thiopentone (Na) is a very short-acting barbiturate, used intravenously as a depressant for central nervous system, induces hypnosis and anesthesia but not analgesia. Thiopentone (Na) is used for short duration anesthesia or for induction of anesthesia prior to use of other anesthetics.
Primary Characteristics
Thiopentone (Na) is also known as Thiopental.
It belongs to Thiobarbiturate.
It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action. It is also classified under General Anesthetics .
Molecular Weight: 264.3 · pKa: 7.6 · Solubility in Water: 1 in 1.5 · Solubility in Alcohol: 1 in 10 - 30 · Non-proprietary name: Thiopentone (Na) · pH: 10.3 · Isotonic value: 3.5.
Pharmacokinetics
Distribution: Thiopentone (Na) has a volume of distribution is 2.5 l/kg. plasma protein binding is 50 - 80 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 4 -12 hr.
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Indications
Thiopentone (Na) is primarily indicated in conditions like Convulsions, Induction of anaesthesia, Induction of general anaesthesia, Reduction of raised intracranial pressure.
Thiopentone (Na) is also indicated for secondary conditions like Cerebral ischaemia.
Contraindications
Thiopentone (Na) is contraindicated in conditions like Porphyria.
Dosage
Thiopentone (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2625 mg | 2625 mg | — | IV | As Required |
| Paediatric Dosage (20kg) | ||||
| 4.5 mg/kg | 4.5 mg/kg | — | Intra Venous | Single Dose |
| Neonatal Dosage (3kg) | ||||
| 4.5 mg/kg | 4.5 mg/kg | — | Intra Venous | Single Dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Thiopentone (Na) produces potentially life-threatening effects which include Apnea, Respiratory depression, Hypotension, CNS depression, Myocardial depression. Careful monitoring is needed with proper medical management.
Thiopentone (Na) is known to cause more or less tolerable side effects which are usually transient. These include Bronchospasm, Cough , Hiccough , Laryngospasm .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.1.1.1 — Intravenous agents