Sulpiride

Drug #695

Sulpiride is antipsychotic agent with similar action and uses as for chlopromazine. Sulpiride is used in the treatment of schizophrenia, also given for the management of anxiety, vertigo and peptic ulceration.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzamide.

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 341.4 · pK_a: 8.9 · Solubility in Water: Insoluble · Solubility in Alcohol: Weakly Soluble · Non-proprietary name: Sulpiride.

Pharmacokinetics

Absorption: Sulpiride has an oral bioavailability is 32.5% (±7.5%).

Distribution: Sulpiride has a volume of distribution is 0.65 - 1.4 L/kg. plasma protein binding is 14 %.

Elimination: plasma half-life is 6 - 8 hr, renal excretion is Extensive.

Indications

Sulpiride is primarily indicated in conditions like Control of muscarinic side-effects of neostigmine, Depression, Psychosis, Schizophrenia.

Contraindications

Sulpiride is contraindicated in conditions like Epilepsy, Phaeochromocytoma, Porphyria.

Dosage

Sulpiride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
300 mg	300 mg	Every 12h	PO	Max.800 mg daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
0 – 0	—	—		Not indicated in this age group

Drug Interactions

Unknown11 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sulpiride in overdosage may give rise to further complications which include Tardive dyskinesia .

Sulpiride produces potentially life-threatening effects which include Hepatitis , Malignant neuroplastic syndrome, Hypertensive crises. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sulpiride are Hypotension, Confusion , Agitation, Extrapyramidal effects , Restlessness .

Sulpiride is known to cause more or less tolerable side effects which are usually transient. These include Acute dystonia, Akathisia, Anxiety, Elevated alkaline phosphatase, Elevated aminotransferase, Excitement, Irritability, Leukopenia, Mood swings, Parkinsonism.

Warnings / Precautions

Sulpiride should be given with care to manic or hypomanic patients in whom it may exacerbate symptoms. It should be used with care during pregnancy, avoid use during lactation. It should be used with caution in patients with impaired renal function.

Interference in Pathology

Sulpiride may interfere in the diagnosis of Test for Estimating Glucose and Cholestrole Conc. in Serum .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

100 mg 25 mg 50 mg

Storage Conditions

Sulpiride should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders

Manufacturers

Manufacturers of Sulpiride in Pakistan:

Medizan Lab Usawa