Sulphinpyrazone
Also known as: Sulfinpyrazone
Sulphinpyrazone is a sulfoxide analogue of phenylbutazone. Sulphinpyrazone is used as an uricosuric agent. Sulphinpyrazone is organic acid and act at the anionic transport sites of the renal tubule. Sulphinpyrazone is employed to decrease the body pool of urate in patients with tophaceous gout or in those with frequent gouty attacks. Sulphinpyrazone is not used for acute attacks of gout. It has been studied as an antithrombotic agent.
Primary Characteristics
Sulphinpyrazone is also known as Sulfinpyrazone.
It is of Synthetic origin and belongs to Phenylbutazone.
It belongs to Renal tubular anion resorption inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 404.5 · pKa: 2.8 · Solubility in Water: slightly soluble · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Sulphinpyrazone.
Pharmacokinetics
Absorption: Sulphinpyrazone has an oral bioavailability is 95% (±5%).
Distribution: Sulphinpyrazone has a volume of distribution is 0.06 l/kg. plasma protein binding is 98 - 99 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 6 hr, renal excretion is extensive.
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Indications
Sulphinpyrazone is primarily indicated in conditions like Gout prophylaxis, Infertility without hyperprolactinaemia, Mild to moderate endometriosis.
Contraindications
Sulphinpyrazone is contraindicated in conditions like Gout, Peptic ulcer, Renal failure, Nephrolithiasis, Hepatic disease.
Dosage
Sulphinpyrazone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.71 mg/kg | 0.71 mg/kg | Every 8h | PO | Initially for 2-3 Weeks |
| 3.33 mg/kg | 3.33 mg/kg | Every 8h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Sulphinpyrazone in overdosage may give rise to further complications which include Bleeding from pre-existing ulcer disease , Hematuria, Renal colic .
Sulphinpyrazone produces potentially life-threatening effects which include Blood dyscrasias. Careful monitoring is needed with proper medical management.
Sulphinpyrazone is known to cause more or less tolerable side effects which are usually transient. These include Epigastric discomfort, Nausea, Skin rashes.
Warnings / Precautions
Interference in Pathology
Sulphinpyrazone may interfere in the diagnosis of Test for Renal Blood Flow Measurement .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.3 — Antigout preparations