Sufentanil (Citrate)

Drug #682

Sufentanil (Citrate) is opiod analgesic. Sufentanil (Citrate) is given parentrally as an adjunct in anesthesia and as a primary anesthetic drug in procedurers requiring assisted ventilation. Sufentanil (Citrate) is highly lipid-soluble and the onset of action is rapid with a more rapid recovery than fentanyl..

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Primary Characteristics

It is of Synthetic origin and belongs to Opioid.

It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 578.7 · pK_a: 8.01 · Non-proprietary name: Sufentanil (Citrate).

Molecular structure of Sufentanil (Citrate)

Pharmacokinetics

Absorption: Sufentanil (Citrate) has an oral bioavailability is 105%.

Distribution: Sufentanil (Citrate) has a volume of distribution is 2.86 l/kg. plasma protein binding is 92 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 2 - 5 hr, renal excretion is 6%.

Indications

Sufentanil (Citrate) is primarily indicated in conditions like Pain.

Sufentanil (Citrate) is also indicated for secondary conditions like Anesthesia.

Contraindications

Sufentanil (Citrate) is contraindicated in conditions like Hypovolaemia, Respiratory depression.

Dosage

Sufentanil (Citrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.1 ug/kg	0.1 ug/kg	—	IV	As Required
Paediatric Dosage (20kg)
17.5 ug/kg	17.5 ug/kg	—	Intavenous	As required
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sufentanil (Citrate) in overdosage may give rise to further complications which include Tonic-clonic seizures .

Sufentanil (Citrate) produces potentially life-threatening effects which include Respiratory depression. Careful monitoring is needed with proper medical management.

Sufentanil (Citrate) is known to cause more or less tolerable side effects which are usually transient. These include Nausea and vomiting.

Warnings / Precautions

Sufentanil should be used with caution in patients with central nervous system (CNS) depression, convulsive disorder, ulcerative colitis, fever, recent gastrointestinal (GI) surgery, bradyarrhythmias, supraventricular tachycardia, pulmonary diseases. Patients should exercise caution while driving or performing tasks requiring alertness because it may produce drowsiness.

Available Brands

None recorded.

Storage Conditions

Sufentanil (Citrate) should be stored Inj.

Drug Classification

1.2.2 — Opioid analgesics