Streptozotocin

Also known as: Streptozocine

Drug #680

Streptozotocin is antineoplastic antibiotic derived from Streptomyces achromogenes or produced by chemical synthesis. Streptozotocin is the drug of choice in the of treatment of malignant pancreatic insulinomas and malignant carcinoid tumors (especially when given along with Fluorouracil). Streptozotocin is also effective in the treatment of Hodgkin`s disease and for colon cancer, when used in combination with other anticancer drugs.

← Previous drug Next drug →

Primary Characteristics

Streptozotocin is also known as Streptozocine.

It is of Synthetic origin and belongs to Glucopyranose.

It belongs to DNA Strand Breakage pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 265.2 · Solubility in Water: very soluble · Solubility in Alcohol: soluble · Non-proprietary name: Streptozotocin.

Pharmacokinetics

Elimination: plasma half-life is 35 - 40 min, renal excretion is 70 %.

Indications

Streptozotocin is primarily indicated in conditions like Islet cell pancreatic tumor, Pancreatic cancer.

Contraindications

Streptozotocin is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Streptozotocin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mg/sq.meter	500 mg/sq.meter	Every 24h	IV	For 5 Days
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

1 interaction

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Streptozotocin in overdosage may give rise to further complications which include Brain neoplasm , Gi bleeding , Myocardial infarction , Confusion , Increased intracranial pressure , Pulmonary fibrosis .

Streptozotocin produces potentially life-threatening effects which include Bone marrow suppression, Renal failure, Hepatic failure, Perforation of large intestine . Careful monitoring is needed with proper medical management.

Streptozotocin is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Diarrhea, Fever, Hypotension , Limb paresthesia, Nausea, Skin ulcers, Slurred speech, StomatitisX, Thrombophlebitis , Tremor, Urticaria, Vomiting .

Warnings / Precautions

Streptozotocin is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled. Avoid use in patient with impaired kidney or liver function.

Available Brands

None recorded.

Storage Conditions

Streptozotocin should be stored Inj (reconstituted soln) .

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs