Azatadine (Maleate)

Drug #68

Azatidine is an antihistaminic agent with actions, uses and adverse effects similar to PROMETHAZINE. It provides relief of symptoms of allergic reactions such as rash, hives, watery eyes, runny nose, itchy eyes and sneezing.

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Primary Characteristics

It is of Synthetic origin and belongs to Piperidyl Benzo Pyridine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 522.6 · pK_a: 8.4 · Solubility in Water: 1 in 30 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Azatadine (Maleate).

Molecular structure of Azatadine (Maleate)

Pharmacokinetics

Absorption: Azatadine (Maleate) has an oral bioavailability is 94.5% (±4.5%).

Distribution: Azatadine (Maleate) has a volume of distribution is 0.88 l/kg. plasma protein binding is very Low.

Elimination: it is metabolised via not known, plasma half-life is 8.7 hr, renal excretion is 57%.

Indications

Azatadine (Maleate) is primarily indicated in conditions like Allergic pruritis, Allergic rhinitis, Hay fever, Urticaria, Vasomotor rhinitis.

Contraindications

Azatadine (Maleate) is contraindicated in conditions like Glucoma, Prostatic hypertrophy, Pyloric disease, Pyloric stenosis, Hypersensitivity, Urinary retention.

Dosage

Azatadine (Maleate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.014 mg/kg	0.014 mg/kg	Every 12h	PO	-
Paediatric Dosage (20kg)
0.025 mg/kg	0.025 mg/kg	Every 12h	Oral	-
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended n this age group

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Azatadine (Maleate) are Tachycardia , Urinary retention, Dry mouth, Blurred vision, Drowsiness, Confusion .

Azatadine (Maleate) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Drowsiness, Dry mouth, Dysuria, Headache, Mood changes, Nausea, Vertigo.

Warnings / Precautions

Azatadine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer azatadine subcutaneously because irritation or lesion may occur.

Available Brands

None recorded.

Storage Conditions

Azatadine (Maleate) should be stored tabs.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis