Pyridoxine

Also known as: Vitamin B6, Adermine HCl

Drug #637

Pyridoxine, or vitamin B6, is a naturally occurring, water-soluble vitamin found in food such as cereal grains, legumes, vegetables, liver, meat, and eggs. Pyridoxine is used to treat and prevent vitamin B6 deficiency; to prevent or treat toxicity from isoniazid, cycloserine, or hydralazine; and to treat sideroblastic anemia associated with elevated serum iron levels. It also has been used in pyridoxine-dependent neonates to treat seizures that are unresponsive to conventional therapy and in patients with metabolic disorders such as xanthurenic aciduria, primary hyperoxaluria, primary cystathioninuria, and primary homocystinuria. Pyridoxine hydrochloride has been commercially available since approval by the FDA in 1940.

← Previous drug Next drug →

Primary Characteristics

Pyridoxine is also known as Vitamin B6, Adermine HCl, Pyridoxine HCl.

It is of Synthetic origin and belongs to Pyridine.

It belongs to Nutrients and Vitamins pharmacological group on the basis of mechanism of action.

Molecular Weight: 205.6 · pK_a: 5.0, 9.0 · Solubility in Water: 1 in 5 · Solubility in Alcohol: 1 in 115 · Non-proprietary name: Pyridoxine (HCl) · pH: 3.2 · Isotonic value: 3.05.

Pharmacokinetics

Absorption: Pyridoxine has an oral bioavailability is 73% (±2%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Elimination: it is metabolised via Hepatic, plasma half-life is 15 - 20 days, renal excretion is extensive.

Indications

Pyridoxine is primarily indicated in conditions like Anaemia, Deficiency states, Idiopathic sideroblastic anaemia, Isoniazid neuropathy, Oedema and ascites in cirrhosis of the liver, Premenstrual syndrome, Schizophrenia and other psychoses, Vitamin deficiency.

Contraindications

None recorded.

Dosage

Pyridoxine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 24h	PO, IV, IM	Dose vary according to indication, Daily requirement 1.7-2mg
Paediatric Dosage (20kg)
0.75 mg/kg	0.75 mg/kg	Every 8h	Oral
Neonatal Dosage (3kg)
0.75 mg/kg	0.75 mg/kg	Every 8h	Oral

Drug Interactions

Unknown6 interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pyridoxine in overdosage may give rise to further complications which include Numbness , Neurotoxicity , Hyperesthesia, Bone pain , Paresthesia, Muscular weakness .

The signs and symptoms that are produced after acute overdosage of Pyridoxine are Hypervitaminosis , Neuropathy .

Pyridoxine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Burning, Dizziness, Drowsiness, Pain .

Warnings / Precautions

Some drugs increase pyridoxine requirements, these are cycloserine, hydralazine, isoniazid, oral contraceptives and penicillamine. It should be used with caution during lactation. Avoid long term administration of large doses of pyridoxine because may cause severe peripheral neuropathies.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

50 mg

Multi-Ingredient Combinations

Caps

0.5 mg 1 mg 100 mg 12.15 mg 2 mg 20 mg 200 mg 25 mg 40 mg 5 mg 8 mg

Caps

10 mg 3 mg

Dragees

10 mg

Dragees

2 mg

Drops

0.5 mg/0.6ml 1 mg/0.6ml 2 mg/ml

Inf

15 mg/10ml 40 mg/L 5 mg/ml

Inj

1.5 mg/ml 10 mg/ml 100 mg/3ml 4 mg/ml

Inj

Inj-IV

Liquid

Liquid

Sachet

10 mg 15 mg 2.5 mg 5 mg

Soft Caps

1 mg

Susp

8 mg/5ml

Syrup

0.2 mg/5ml 0.77 mg/5ml 1.666 mg/5ml 10 mg/5ml 16.66 mg/5ml 3 mg/5ml 4 mg/5ml 45 mg/5ml

Tabs

0.5 mg 1 mg 1.05 mg 1.5 mg 10 mg 100 mg 2 mg 2.5 mg 2.6 mg 20 mg 200 mg 25 mg 3 mcg 3 mg 3.3 mg 37 mg 4 mg 5 mg 50 mg

Tabs Chewable

1 mg

Tabs efr

10 mg 5 mg

Storage Conditions

Pyridoxine should be stored Tab.

Drug Classification

1.27 — Vitamins, minerals, tonics, and other susbstances