Primaquine (Phosphate)

Drug #600

Primaquine (Phosphate) is antimalarial agent. Primaquine (Phosphate) is a synthetic 8-aminoquinoline derivative. Primaquine (Phosphate) is effective against the late hepatic stages of Plasmodium vivax and Plasmodium ovale and the primary exoerythrocytic stages of Plasmodium falciparum.

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Primary Characteristics

It is of Synthetic origin and belongs to Quinolone.

It belongs to Antiplasmodial pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.

Molecular Weight: 455.3 · Solubility in Water: 1 in 16 · Solubility in Alcohol: insoluble · Non-proprietary name: Primaquine (Phosphate).

Molecular structure of Primaquine (Phosphate)

Pharmacokinetics

Absorption: Primaquine (Phosphate) has an oral bioavailability is 101%, pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Primaquine (Phosphate) has a volume of distribution is 3 - 4 l/kg. plasma protein binding is high.

Elimination: it is metabolised via Hepatic, plasma half-life is 4 -10 hr.

Indications

Primaquine (Phosphate) is primarily indicated in conditions like Diagnosis of dual block due to suxamethonium, Iron deficiency anaemia, Malaria, Malaria prophylaxis, NSAID-associated gastric or duodenal ulcers (prophylaxis).

Contraindications

Primaquine (Phosphate) is contraindicated in conditions like G6pd deficiency, Granulocytopenia.

Dosage

Primaquine (Phosphate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 24h	PO	For 14 Days
Paediatric Dosage (20kg)
0.25 mg/kg	0.25 mg/kg	Every 24h	Oral	For 2-3 Weeks
Neonatal Dosage (3kg)
0.25 mg/kg	0.25 mg/kg	Every 24h	Oral	For 2-3 Weeks

Drug Interactions

Unknown1 interaction

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Primaquine (Phosphate) in overdosage may give rise to further complications which include Depression , Cyanosis , Cardiac arrhythmias, Hypertension .

Primaquine (Phosphate) produces potentially life-threatening effects which include Hemolytic anemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Primaquine (Phosphate) are Bone marrow suppression, Vomiting, Hemolysis , Anorexia , Weakness , Nausea, Jaundice , Methemoglobinemia, Cyanosis.

Primaquine (Phosphate) is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Epigastric discomfort, Nausea, Vomiting .

Warnings / Precautions

Primaquine should be used with caution in patients with any pre-existing blood disorders, arthritis, psoriasis, lupus erythematous, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, liver disease or any allergy. It should be used only if clearly needed during pregnancy.

Interference in Pathology

Primaquine (Phosphate) may interfere in the diagnosis of TLC Tests for Barbiturates and Alkaloids in Urine .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

7.5 mg

Storage Conditions

Primaquine (Phosphate) should be stored Tab.

Drug Classification

1.6.4.3 — Antimalarials

Manufacturers

Manufacturers of Primaquine (Phosphate) in Pakistan:

Ethical