Praziquantel

Drug #596

Praziquantel is an anthelmintic drug. It is a synthetic isoquinoline pyrazine derivative. Praziquantel is effective in schistosomal infection of all species and most other trematodes and cestodes infections.

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Primary Characteristics

It is of Synthetic origin and belongs to Isoquinolones.

It is classified in Anthelmintics pharmacological group.

Molecular Weight: 312.4 · pK_a: > 3 · Solubility in Water: very slight · Solubility in Alcohol: soluble · Non-proprietary name: Praziquantel.

Pharmacokinetics

Absorption: Praziquantel has an oral bioavailability is 92.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Praziquantel has a plasma protein binding is 80 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 3 - 8 hr, renal excretion is extensive.

Indications

Praziquantel is primarily indicated in conditions like Fluke infections, Helminth infection, Schistosomiasis.

Contraindications

Praziquantel is contraindicated in conditions like Ocular cysticercosis.

Dosage

Praziquantel 's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg/kg	25 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
22.5 mg/kg	22.5 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown7 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Praziquantel in overdosage may give rise to further complications which include Abdominal pain, Jaundice .

Praziquantel is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Fever, Skin reactions, Sleepiness.

Warnings / Precautions

Patients should be observed caution while driving or performing other tasks requiring alertness, because it may produced drowsiness or dizziness. Avoid use of praziquantel during lactation.

Interference in Pathology

Praziquantel may interfere in the diagnosis of Haemoglobinopathies Tests , G6PD Tests .

Available Brands

None recorded.

Storage Conditions

Praziquantel should be stored Tab .

Drug Classification

1.6.1.1 — Intestinal anthelmintics
2.6.1.3 — Antischistosomals and other anti-trematodes