Prazepam

Drug #595

Prazepam is oral benzodiazepine used for the management of symptoms associated with anxiety disorders and for short-term amelioration of the symptoms of anxiety or anxiety associated with depression. It was approved by the FDA in 1976.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzodiazepine.

It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 324.8 · pK_a: 2.7 · Solubility in Water: Insoluble · Solubility in Alcohol: > 1 in 30 · Non-proprietary name: Prazepam.

Pharmacokinetics

Absorption: Prazepam has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 96.5% (±1.5%).

Distribution: Prazepam has a volume of distribution is 0.5 - 2.5 l/kg. plasma protein binding is 97 %.

Elimination: plasma half-life is 30 - 200 hr.

Indications

Prazepam is primarily indicated in conditions like Alcohol withdrawal, Anxiety, Insomnia, Muscular spasm.

Contraindications

Prazepam is contraindicated in conditions like Psychosis, Pulmonary insufficiency, Respiratory depression, Phobias.

Dosage

Prazepam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 24h	PO	At bed time
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown7 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Prazepam in overdosage may give rise to further complications which include Confusion , Diarrhoea , Insomnia , Irritability , Nervousness , Psychosis , Sweating , Depression .

The signs and symptoms that are produced after acute overdosage of Prazepam are Unconsciousness, Respiratory depression, Ataxia, Dizziness, Slurred speech.

Prazepam is known to cause more or less tolerable side effects which are usually transient. These include Aggression, Ataxia, Blurred vision, Confusion, Drowsiness, Excitement, Paradoxical effects, Psychotic symptoms, Sedation .

Warnings / Precautions

Perform periodic blood counts and liver function tests during long term therapy. Prazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine)in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).

Available Brands

None recorded.

Storage Conditions

Prazepam should be stored Caps.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders